 | | Vol. 17.43 – 9 November, 2022 |
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| Scientists characterized the regulatory program underlying heterogeneity in mESC states by identifying differentially active and transcribed enhancers across states.
[Molecular Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that membrane voltage regulated the exit from pluripotency and the onset of germ layer differentiation in the embryo, a process that affected both gastrulation and left-right patterning.
[Nature Communications] |
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| The authors showed that lamin A/C played a key role in chromatin organization in ESCs, which safeguarded naïve pluripotency and ensured proper cell fate choices during cardiogenesis.
[Nature Communications] |
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| Investigators demonstrated that perturbation of an ESC/early embryonic long non-coding RNA (lncRNA), pluripotency-associated transcript 4 (Platr4), directly influenced the specification of cardiac-mesoderm-lineage differentiation.
[Developmental Cell] |
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| Researchers reported that exit from stemness and differentiation of pluripotent cells along the neural lineage were controlled by CDC14, a cyclin-dependent kinase-counteracting phosphatase.
[EMBO Journal] |
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| Scientists showed that mESCs, which displayed rapid cell cycles and spent little time in G1, also displayed accelerated reactivation dynamics that lacked specificity towards functional gene families, enabling the restoration of all regulatory functions before DNA replication.
[EMBO Reports] |
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| Investigators developed a minimal gene regulatory network model of hPSC lineage commitment and embedded it into “cellular” agents that responded to a dynamic morphogenetic signaling microenvironment.
[Stem Cell Reports] |
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| The authors derived four hESC lines in naïve human stem cell medium (NHSM), and generated isogenic pairs of NHSM and primed cultures. Through phenotypic, transcriptomic, and methylation profiling, they identified changes that arose during the transition to a primed substate.
[iScience] |
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| Researchers identified several interaction partners of Strip2, one component of the striatin-interacting phosphatase and kinase complex, which was primarily involved in the regulation of the pluripotency of ESCs and their differentiation.
[Cell Death Discovery] |
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| Scientists explored the consequences of acute hypoxia on hPSC survival by culturing them under acute physical severe hypoxia.
[Scientific Reports] |
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| The authors highlight recent progress in iPSC editing and guided differentiation to develop natural killer (NK) and T cell products for immunotherapy.
[Blood] |
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| The FDA committed to exploring alternative methods to replace laboratory animals in developing new drugs and products.
[Nature News] |
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| May 4 – 7, 2023
Riviera Maya, Mexico |
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| | Berlin Institute of Health – Berlin, Germany |
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| | Lifespan – Providence, Rhode Island, United States |
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| | UC San Francisco – San Francisco, California, United States |
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| | University of Galway – Galway, Ireland |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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