 | | Vol. 17.44 – 16 November, 2022 |
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| The authors identified podocalyxin-like protein 1 (PODXL) as being essential for extended and primed pluripotency. Alteration of PODXL expression levels affected self-renewal, protein expression of c-MYC and telomerase, and iPSC and extended PSC colony formation.
[Advanced Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers generated immunocytochemical, electrophysiological, and proteomic data from iPSC-derived neurons of five healthy subjects, analyzed data variation, and conducted power simulations. These analyses showed that published case-control iPSC studies were generally underpowered.
[Molecular Psychiatry] |
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| Scientists showed that Mcm2, a subunit of the Mcm2-7 helicase best known for its role in DNA replication, was important for the differentiation of mESCs.
[eLife] |
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| By recapitulating a laminin component of the extracellular matrix niche during embryonic formative transition and defined culture conditions, investigators generated cultures highly enriched for self-renewing hPSCs, exhibiting properties of early post-implantation epiblast cells.
[Stem Cell Reports] |
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| Researchers found that knockout of the mismatch repair gene MSH2 resulted in an immediate survival advantage in human stem cells grown under standard cell culture conditions.
[Stem Cell Reports] |
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| Scientists reported a method for better maintaining XX female mESCs in culture, which also stabilized the male karyotype, and made study of female specific pluripotency more feasible.
[Development] |
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| The authors systematically assessed medium components, coatings, and growth factors required for iPSC differentiation to microglia.
[Scientific Reports] |
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| Metabolomics and transcriptomics analyses were used to investigate the effects of low-density feeder cells on bovine ESCs.
[Theriogenology] |
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| To study the competitive proliferation and differentiation of hESCs, researchers obtained cells of H9 hESC line that stably expressed green fluorescent protein.
[International Journal of Radiation Biology] |
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| The author describes the whole molecular process of UHRF1–DNMT1 pathway and lists some latest biological research progress related to this pathway in the development of early embryos and maintenance of pluripotency of ESCs.
[Functional & Integrative Genomics] |
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| Wesleyan University received $1.7 million in early-stage funding from the National Institutes of Health to find an answer to an urgent question: “What’s the first thing that goes wrong, that snowballs into the pathology that we see later in Alzheimer’s disease?”.
[Connecticut Public] |
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| June 22 – 23, 2022
Oslo, Norway |
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| | Institut Curie – Paris, France |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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| | University of Bristol – Bristol, Engand, United Kingdom |
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| | Babraham Institute – Babraham, England, United Kingdom |
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| | King’s College London – London, England, United Kingdom |
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