 | | Vol. 17.45 – 23 November, 2022 |
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| Starting from an RNA interference (RNAi) screen of RNA helicases, investigators identified that eIF4A3, a DEAD-box helicase component of the exon junction complex, was essential for the maintenance of ESCs.
[Nucleic Acids Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Synthetic gene circuits with sense-and-respond capabilities were designed to detect cell states and perform cell-state-specific control of desired protein expression in hPSCs.
[Molecular Systems Biology] |
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| Six different auxetic polyurethane foams with different elastic modulus and Poisson’s ratio were used to investigate lineage specification of hiPSCs.
[Advanced Healthcare Materials] |
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| Researchers showed that BNIP3-dependent mitophagy protected genomic integrity in mESCs. Deletion of Bnip3 increased cellular reactive oxygen species and decreased ATP generation.
[Cell Death & Disease] |
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| Scientists showed that hiPSCs and hiPSC-derived ectodermal, mesodermal, and endodermal cells were susceptible to Influenza A virus (IAV) infection. These cell types stained positive for α2,6-linked sialic acid, the receptor for IAV infection expressed on the cell surface.
[Virus Research] |
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| During retinoic acid-mediated differentiation of mESCs, autophagy was induced, and the Polycomb group histone methyl transferase EZH2 was identified as a regulator of this process.
[The FEBS Journal] |
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| The authors showed that naïve PSCs depleted of β-catenin remained dependent on XAV939. XAV939 prevented trophectoderm induction by reducing activation of YAP.
[Development] |
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| Investigators generated hESCs lacking retinoblastoma tumor suppressor (RB) family proteins by introducing frameshift mutations in RBL1 and RBL2 genes using the CRISPR/Cas9 technology, and then integrating the short hairpin RNA-expression cassette to knockdown RB upon tetracycline treatment.
[PLoS One] |
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| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoenzyme expressions were analyzed in R1 and J1 mESCs that were cultured in the presence and absence of leukemia inhibitory factor.
[Cytotechnology] |
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| The authors review the state of the art of the use of PSCs as a model for hematopoietic and leukemia development.
[Stem Cells Translational Medicine] |
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| Scientists summarize the iPSC modeling approach of Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, as well as outline typical mitochondrial dysfunction and recapitulate corresponding therapeutic strategies.
[Frontiers in Cell and Developmental Biology] |
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| Prepaireâ„¢ Labs and Ncardia announced the signing of a 5-year agreement. The potential outcome of this partnership will accelerate aspects of drug discovery and development, including target discovery, lead optimization, toxicity assessment, and trial design.
[Prepaire (EIN Presswire)] |
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| September 19, 2023
Virtual |
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| | City of Hope – Los Angeles, California, United States |
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| | Institut Curie – Paris, France |
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| | University of Bristol – Bristol, England, United Kingdom |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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| | Babraham Institute – Babraham, England, United Kingdom |
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