 | | Vol. 17.46 – 30 November, 2022 |
| |
|
|
| Based on de novo motif searches, scientists identified the orphan nuclear receptor Nr5a2 as a key activator of major zygotic genome activation in mouse 2-cell embryos. Nr5a2 was required for progression beyond the 2-cell stage.
[Science] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Researchers showed that transactive response (TAR) DNA-binding protein 43 (TDP-43), mutations in which constitute a major risk factor for amyotrophic lateral sclerosis, inhibited long interspersed nuclear element-1 (L1) retrotransposition in mESCs and preimplantation embryos.
[Science Advances] |
|
|
|
| Investigators showed that telomeric-repeat containing RNA (TERRA) modulated ATRX occupancy on repetitive sequences and over genes, and maintained DNA G-quadruplex structures at TERRA target and non-target sites in mESC.
[Nucleic Acids Research] |
|
|
|
| By quantitatively examining dynamic ranges of gene expression, the authors found that Oct4 and Sox2 enhancer binding was strongly enriched near genes subject to large dynamic ranges of expression among cell types, with binding sites near these genes usually within superenhancers.
[Genes & Development] |
|
|
|
| Researchers developed a cellular model to study sex differences in humans. Somatic cells from a mosaic Klinefelter syndrome patient were reprogrammed to generate isogenic iPSC lines with different sex chromosome complements: 47, XXY/46, XX/46, XY/45, and X0.
[Stem Cell Reports] |
|
|
|
| Scientists analyzed naive pluripotent and trophoblastic stem cells and discovered 4 new missing proteins, thus contributing to the Chromosome-centric Human Proteome Project.
[Journal of Proteome Research] |
|
|
|
| The authors compared three methods to delete the 2.5-Mb Krüppel-associated box zinc finger protein gene cluster in mESCs using CRISPR-Cas9: (i) deletion by non-homologous end joining; (ii) homology-directed repair (HDR); (iii) HDR employing targeting vectors with a selectable marker and 1-kb homology arms.
[DNA Research] |
|
|
|
| Investigators explored intracellular molecular changes during the differentiation of hiPSCs into erythropoietin-producing cells using Raman spectroscopy and imaging.
[Scientific Reports] |
|
|
|
| Scientists reprogrammed proximal tubule cells and tail tip fibroblasts from a reprogrammable mouse to iPSCs and differentiated the iPSCs to renal progenitors to understand if epigenetic memory played a role in renal differentiation.
[Scientific Reports] |
|
|
|
| Researchers established ESCs from Sox10-Venus+ mice. These cells were cultured for 2 days, then selected and co-cultured with either a dissociated control or Sox10-Venus–Ednrb KO mouse gut on embryonic day 13.5.
[Pediatric Surgery International] |
|
|
|
|
| The authors provide a simplistic overview of the current progress and advancements after synthesizing the enormous literature on schizophrenia (SCZ) genetics and SCZ iPSC-based models.
[Schizophrenia Research] |
|
|
|
|
| UCI Health and UCI Alpha Clinic have launched the first and only US clinical trial to test the safety and tolerability of IMM01-STEM in patients with muscle atrophy related to knee osteoarthritis.
[UCI Health] |
|
|
|
|
| April 25 – 26, 2023
London, England, United Kingdom |
|
|
|
|
|
| | Leiden University Medical Center – Leiden, Netherlands |
|
|
|
| | University of Edinburgh – Edinburgh, Scotland, United Kingdom |
|
|
|
| | City of Hope – Los Angeles, California, United States |
|
|
|
| | Institut Curie – Paris, France |
|
|
|
| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
