 | | Vol. 17.48 – 14 December, 2022 |
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| Researchers used Hofstenia miamia, a regenerative worm that possesses adult PSCs called neoblasts and produces manipulable embryos. Lineage tracing and functional experiments revealed that one pair of blastomeres gave rise to cells that resembled neoblasts in distribution, behavior, and gene expression.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| A light-inducible cell reprogramming system was developed based on a photoreceptor protein cryptochrome system and clustered regularly interspaced short palindromic repeats/nuclease-deficient CRISPR-associated protein 9 for iPSC reprogramming.
[Advanced Science] |
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| To identify non-nuclear regulators of ESCs, scientists screened an endogenously labeled fluorescent fusion-protein library in mESCs. Cell-cycle-associated protein 1 (CAPRIN1) knockout had little effect in ESCs, but it significantly altered differentiation and gene expression programs.
[Developmental Cell] |
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| Investigators observed enrichment of Krüppel-like factor 4 (KLF4) at some poised or closed enhancers at transcription start site-linked regions of genes associated with neural differentiation. Combination analysis of ChIP, HiChIP, and RNA-seq data indicated that KLF4 loss in ESCs induced changes in 3D chromatin structure.
[Nucleic Acids Research] |
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| The authors tested prophylactic and therapeutic bladder cancer vaccines composed of allogeneic ESCs and CpG with or without GM-CSF.
[Advanced Healthcare Materials] |
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| Scientists showed that mitophagy was a prerequisite for reversible quiescence in both irradiated Drosophila germline stem cells and hiPSCs.
[Stem Cell Reports] |
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| To increase the versatility of bioluminescence microscopy, investigators presented an improved low-light microscope in combination with deep learning methods to image extremely photon-starved samples enabling subsecond exposures for timelapse and volumetric imaging.
[Communications Biology] |
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| Researchers first compared the knock-in (KI) efficiency of mESCs with CRISPR/Cas9 expression vector and ribonucleoprotein (RNP), and confirmed that KI efficiency was significantly increased by using RNP.
[Scientific Reports] |
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| The authors explored the requirement for the downstream signaling transducer and activator of transcription, STAT3, and its target, TFCP2L1, in the maintenance of naïve pluripotency.
[Biology Open] |
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| Investigators discuss the current US federal and state regulatory environment. A unique approach of presenting anonymized embryo donor statements is provided to personalize the decision-making process of human embryo donation for hESC derivation.
[Fertility and Sterility] |
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| UC Davis Health’s Alpha Stem Cell Clinic has received an $8 million grant renewal from the California Institute for Regenerative Medicine. The funding will allow the clinic to expand its successful clinical trials operation and advance toward onsite manufacturing of therapies.
[UC Davis Health] |
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| June 14 – 17, 2023
Boston, Massachusetts, United States |
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| | Westlake University – Hangzhou, China |
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| | Max Delbrück Center for Molecular Medicine – Berlin, Germany |
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| | University of Bristol – Bristol, England, United Kingdom |
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| | City of Hope – Los Angeles, California, United States |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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