 | | Vol. 18.00 – 4 January, 2023 |
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| Using mESCs as a model, scientists revealed that the mouse R783H mutation, R796H in human, altered Trim71’s mRNA substrate specificity and led to accelerated stem-cell differentiation and neural lineage commitment.
[Embo Reports] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Within the scope of the FANTOM6 consortium, researchers performed a large-scale knockdown of 200 long non-coding RNAs in iPSCs and systematically characterized their roles in self-renewal and pluripotency.
[Cell Reports] |
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| Investigators reported that human coilin-interacting nuclear ATPase protein (hCINAP) served as a negative regulator of Yes-associated protein 1 (YAP1) during ESC fate decisions.
[Cell Reports] |
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| Scientists used a defined medium containing Activin A, WNT activator, and leukemia inhibitory factor (ACL medium), enabling establishment of ACL-ESCs and ACL-XEN cells from one blastocyst.
[Cell Proliferation] |
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| To improve the homogeneity, antigen-specificity, and reduce possible autoreactivity, investigators developed a technique to generate antigen-specific T cells from Rag2 gene-deleted PSCs and further measured their anti-tumor efficacy.
[Cell Proliferation] |
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| Researchers demonstrated that the expression of targeting protein for Xklp2 (TPX2) led to BCL2L1 induction and consequent survival traits under mitotic stress in isogenic pairs of hESCs and iPSCs with normal and 20q11.21 copy number variations.
[Experimental & Molecular Medicine] |
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| Scientists examined the structure and dynamics of the nuclear lamina in hiPSCs and differentiated germ layer cells, focusing on Lamin B1.
[Molecular Biology of the Cell] |
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| The authors showed that the reprogramming factors, OCT4, SOX2, and KLF4, elicited dramatic reprogramming stress even without the pro-oncogene MYC.
[iScience] |
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| Investigators tested the effect of ESC-extracellular vesicles on the replicative senescence model of retinal pigment epithelial cells as well as its mechanism.
[Experimental Eye Research] |
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| By applying the in vitro differentiation of mouse pluripotent P19 cell line into neuron-like cells through retinoic acid treatment, the roles of some genes including DNMT3B, ICAM1, IRX3, JAK2, LHX1, SOX9, TBX3 , and THY1 in neural differentiation was investigated.
[Molecular Biology Reports] |
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| Scientists showed that ESCs in three-dimensional aggregates did not succumb to extruded syntaxin4 owing to suppressed expression of P-cadherin protein.
[Cell Structure and Function] |
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| The authors provide an overall review regarding the study of ESCs in mammals and briefly discuss the role of transcription and growth factors.
[Tissue And Cell] |
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| STEMCELL Technologies announced that its President and CEO, Dr. Allen Eaves, has been appointed to the Order of Canada by Her Excellency the Right Honorable Mary Simon, the Governor General of Canada.
[STEMCELL Technologies] |
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| April 25 – 26, 2023
Boston, Massachusetts, United States |
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| | University Medical Center Freiburg – Freiburg, Germany |
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| | US FDA – Silver Spring, Maryland, United States |
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| | Tulane University – New Orleans, Louisiana, United States |
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| | NIH National Center for Advancing Translational Sciences – Rockville, Maryland, United States |
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| | Rutgers Biomedical and Health Sciences – Newark, New Jersey, United States |
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