 | | Vol. 18.01 – 11 January, 2023 |
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| Scientists showed that ZFP462 safeguarded neural lineage specification of mESCs by targeting the H3K9-specific histone methyltransferase complex G9A/GLP to silence meso-endodermal genes.
[Nature Cell Biology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers examined the role of the RNA-binding protein polypyrimidine tract-binding protein 1 (PTBP1) in the process of spliceosomal intron excision using an acute depletion approach followed by the analysis of chromatin- and RNA Pol II-associated transcripts.
[Molecular Cell] |
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| Investigators reduced the complexity of how a subset of expressed genes dictates cellular phenotype by focusing on cellular organization and generated the WTC-11 hiPSC Single-Cell Image Dataset v1, which contained more than 200,000 live cells in 3D, spanning 25 key cellular structures.
[Nature] |
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| Using PSCs, the authors have established an in vitro system that recapitulated the twofold difference in developmental rate between mouse and human embryos.
[Nature] |
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| Researchers found that in pluripotent mESCs, ERK1/2 did not translocate to the nucleus either before or after stimulation. This inhibition of nuclear translocation might be dependent on a lack of stimulated ERK1/2 interaction with importin7 rather than a lack of ERK1/2 phosphorylation activating translocation.
[Stem Cell Reports] |
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| To study the contribution of duplicated genes to human early development, investigators examined the evolution and function of NANOGP1, a tandem duplicate of the transcription factor NANOG.
[Development] |
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| Scientists investigated whether runt-related transcription factor 1 (RUNX1) played a critical role in mitochondrial dysfunction in Down syndrome and explored the mechanism by which RUNX1 affected mitochondrial functions.
[Molecules and Cells] |
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| The authors showed that BRPF1, a multi-histone binding module protein, was essential for pluripotency in hESCs. BRPF1, H3K4me3, and H3K23ac substantially co-occupied the open chromatin and stemness genes in hESCs.
[iScience] |
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| Researchers demonstrated that RAD21 and REC8 were involved in maintaining genomic stability and modulating chromatin modification in mESCs.
[BMB Reports] |
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| Using pluripotency progression as a paradigm, investigators review how developmental transitions are coordinated by redeployments, rather than global resettings, of cellular components.
[Nature Communications] |
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| The ISSCR announced partnerships with Burroughs Wellcome Fund, Doris Duke Charitable Foundation, and the Simons Foundation Autism Research Initiative to support a new global initiative to develop standards for human stem cell use in research.
[International Society for Stem Cell Research] |
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| April 25 – 26, 2023
London, England, United Kingdom |
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| | Human Technopole – Milan, Italy |
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| | Upstate Medical University – Syracuse, New York, United States |
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| | Columbia University in the City of New York – New York, New York, United States |
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| | Van Andel Research Institute – Grand Rapids, Michigan, United States |
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| | NIH National Center for Advancing Translational Sciences – Rockville, Maryland, United States |
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