 | | Vol. 18.02 – 18 January, 2023 |
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| With mESCs as a testbed, researchers found that differentiating ESCs secreted FGF4 to communicate over many millimeters in cell culture dishes and, thereby, formed a spatially extended, macroscopic entity that grew only if its centimeter-scale population density was above a threshold value.
[Nature Chemical Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that recruitment of polycomb repressive complex 1 (PRC1) and associated molecular functions, ubiquitination of H2AK119, and three-dimensional chromatin interactions, were enhanced during S and G2 phases compared to the G1 phase.
[Nature Communications] |
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| Investigators performed a genome-wide CRISPR–Cas9 screen in mESCs to identify candidates whose depletion rescued the block in cell proliferation induced by O-GlcNAc transferase (OGT) deficiency.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors generated a human recombinant retina-specific laminin isoform, LN523, and demonstrated the role in promoting the differentiation of hESCs into photoreceptor progenitors.
[Molecular Therapy] |
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| Scientists investigated the mechanisms responsible for mitotic errors in hPSCs and showed that the primary cause was lagging chromosomes in anaphase with improper merotelic microtubule attachments.
[Stem Cell Reports] |
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| Researchers integrated transcriptome and H3K9me3 profiles to conduct a detailed comparison of 2-cell (2C) embryos and 2C-like cells. They found that H3K9me3 was highly preserved during 2C-like transition.
[Stem Cell Reports] |
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| Using a comparative study of focal adhesion constituents between mESC and their differentiated counterparts, investigators found while zyxin was lowly expressed in mESCs, its levels increased dramatically during early differentiation.
[Communications Biology] |
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| Researchers demonstrated protein kinase C as an intrinsic master switch between embryonic and extraembryonic cell fates in the differentiation of hPSCs.
[Stem Cells] |
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| Scientists employed Sup F assay for the measurement of mutation frequency after UV-C irradiation in iPSCs as PSC models and neural progenitor cells were derived from iPSCs as differentiated cells.
[Journal of Radiation Research] |
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| The evidence for rDNA transcriptional activity determining stem cell pluripotency is growing as research advances, resulting in the arrest of embryonic development and impairment of stem cell lines stemness by rDNA transcription inhibition.
[Stem Cell Reviews and Reports] |
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| New medicines need not be tested in animals to receive FDA approval, according to legislation signed by President Joe Biden in late December 2022.
[ScienceInsider] |
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| September 22 – 24, 2023
Ribeirao Preto, Brazil |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | MRC National Institute for Medical Research – Cambridge, England, United Kingdom |
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| | Pompeu Fabra University – Barcelona, Spain |
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| | Human Technopole – Milan, Italy |
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| | Upstate Medical University – Syracuse, New York, United States |
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