 | | Vol. 18.03 – 25 January, 2023 |
| |
|
|
| Researchers fused chromosomes 15 and 17 in mouse haploid ESCs (haESCs), resulting in distinct changes of territories in the cognate chromosomes, but with little effect on gene expression, pluripotency, and gamete functions of haESCs.
[Cell Discovery] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Cell nucleus, cytoskeleton, and epigenetic states of hiPSCs on the 5PM binary colloidal crystals were analyzed using atomic force microscopy, molecular biology assays, and the assay for transposase-accessible chromatin sequencing.
[ACS Nano] |
|
|
|
| Scientists interrogated the interplay between tissue organization and morphogens by using hiPSCs downregulated for the morphogen regulator GLYPICAN-4, in which defects in tight junctions resulted in areas of disrupted epithelial integrity.
[Nature Communications] |
|
|
|
| Researchers identified RSL24D1 as highly expressed in both mouse and human PSCs. RSL24D1 was associated with nuclear pre-ribosomes and was required for the biogenesis of 60S subunits in mESCs.
[Nature Communications] |
|
|
|
| Investigators provided an optimized method for reliable and efficient generation of embryonic–trophoblast–extra-embryonic endoderm (ETX) embryoids that developed into late gastrulation in static culture conditions.
[Science Advances] |
|
|
|
| The authors identified a p53-independent quality control factor lncRNA NONMMUT028956 (Lnc956) in mouse ESCs. Lnc956 was prevalently expressed in ESCs and regulated the differentiation of ESCs after DNA damage.
[Science Advances] |
|
|
|
| Scientists established an intersection between LIF-Stat3 signaling that was essential for maintaining mESC pluripotency, and the glycolytic enzyme, the platelet isoform of phosphofructokinase (Pfkp).
[EMBO Reports] |
|
|
|
| Investigators reported that the ribosomal proteins RPL14, RPL18, and RPL23 maintained the identity of mESCs and regulated the expression of 2-cell-stage-specific transcripts.
[Stem Cell Reports] |
|
|
|
| Researchers generated iPSCs from individuals with Down syndrome and euploid controls using urine-derived cells and examined their ability to differentiate into neurons and astrocytes grown in monolayer cultures, as well as into 3D cerebral organoids.
[Stem Cell Reviews and Reports] |
|
|
|
| Scientists systematically studied the self-renewal and differentiation potency of three types of hypoimmunogenic hPSCs: B2Mnull, B2MmHLAG, and B2Mm/sHLAG.
[Stem Cell Research & Therapy] |
|
|
|
| Using microarray profiling, investigators found that the Hippo pathway components vestigial-like family member 4 (VGLL4) and TEA domain transcription factor 1 (TEAD1) were upregulated during vascular smooth muscle cell differentiation from H1 ESCs.
[Journal of Molecular and Cellular Cardiology] |
|  |
|
|
|
| The authors explain the application of stem cells, especially iPSCs and mesenchymal stem cells, in the treatment of cardiovascular diseases with a focus on cellular and molecular mechanisms.
[Tissue and Cell] |
|
|
|
|
| Four Yale faculty members — Shirin Bahmanyar, Anastasia Eccles, Amaleah Hartman, and Jim Wood — had been named recipients of the 2022–23 Poorvu Family Fund for Academic Innovation award, an annual prize that recognizes innovative teaching.
[YaleNews] |
|
|
|
|
| April 23 – 26, 2023
Paris, France |
|
|
|
|
|
| | National University of Ireland Galway – Galway, Ireland |
|
|
|
| | The Ottawa Hospital – Ottawa, Ontario, Canada |
|
|
|
| | University of Copenhagen – Copenhagen, Denmark |
|
|
|
| | European Molecular Biology Laboratory – Barcelona, Spain |
|
|
|
| | MRC National Institute for Medical Research – Cambridge, England, United Kingdom |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
