 | | Vol. 18.04 – 1 February, 2023 |
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| Using in vitro stem cell differentiation and loss of function experiments combined with high-throughput genome-wide bisulfite-, bulk-, and single-cell RNA-sequencing, researchers dissected the specific role of DNMT3B in cell fate.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using the FUCCI reporter, scientists developed a cell-cycle synchronized hPSC differentiation system for uncovering epigenome and transcriptome dynamics during the first two divisions leading to definitive endoderm.
[Nature Communications] |
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| Investigators identified an uncharacterized long noncoding RNA NONMMUT028956 (Lnc956) predominantly expressed in mESCs. Lnc956 was accumulated on replication forks to prevent fork collapse and preserve genomic stability and was essential for mouse embryogenesis.
[Science Advances] |
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| To overcome the paucity of embryos, the authors derived homozygous Dis3 null mESCs to identify additional gene targets of POU6F1.
[Cell Reports] |
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| Researchers established robust methods for iPSC culture in the common marmoset, allowing stable propagation in an undifferentiated state.
[Elife] |
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| To study the contribution of duplicated genes to human early development, investigators examined the evolution and function of NANOGP1, a tandem duplicate of the transcription factor NANOG.
[Development] |
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| Scientists observed that Fam122a deficiency impaired mesendodermal specification and cardiac differentiation from mESCs but showed no influence on pluripotent identity.
[Stem Cells] |
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| The authors comprehensively investigated the gene expression of α subunit of nicotinic acetylcholine receptors (Chrna) during differentiation and induction of PSCs. mESCs expressed multiple Chrna genes in undifferentiated status.
[Scientific Reports] |
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| Investigators reported that coating the glass substrate using nanosheet composed of hydrophobic polystyrene, with Matrigel, significantly improved the viability of hPSCs.
[Biochemical and Biophysical Research Communications] |
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| Scientists review some of the key analytical methods used as part of identity, potency, or safety in process or final product release testing and highlighted the challenges and potential solutions for consideration in the Chemistry, Manufacturing, and Controls strategy for iPSC-based therapies.
[Biotechnology Reports] |
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| Two Karolinska Institute (KI) researchers – Simon Elsässer and Magda Bienko – have been awarded the 2022 European Research Council (ERC) Consolidator Grants that will support two ambitious basic research projects on the understanding of the complex nature of cells.
[Karolinska Institute] |
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| April 23 – 26, 2023
Paris, France |
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| | Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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| | Lund University – Lund, Sweden |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | The Ottawa Hospital – Ottawa, Ontario, Canada |
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| | European Molecular Biology Laboratory – Barcelona, Spain |
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