 | | Vol. 18.05 – 8 February, 2023 |
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| Investigators showed that ZFP266 bound Short Interspersed Nuclear Elements adjacent to binding sites of pioneering factors, OCT4 (POU5F1), SOX2, and KLF4, and impeded chromatin opening.
[Nature Communications] |
|  | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers established robust methods for iPSC culture in the common marmoset, allowing stable propagation in an undifferentiated state.
[Elife] |
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| Scientists used mouse extended stem cells to reconstruct embryo-like structures, furtherly attempting to evaluate the reliability of this model for the prediction of possible developmental toxicity of 2,4,6-triiodophenol.
[Ecotoxicology And Environmental Safety] |
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| The authors reported that RING1 and YY1 binding protein (RYBP) was essential for mouse embryonic development and that Rybp null mutant ESCs cannot form contractile cardiomyocytes in vitro.
[Open Biology] |
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| To induce the differentiation of hiPSCs into oocyte-like cells, cells were firstly cultured with a primordial germ cell medium for 10 days. The cells exhibited similar morphological features to primordial germ cells, high expressing of germ cell markers and primordial follicle development associated genes.
[Stem Cell Reviews And Reports] |
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| Investigators examined the effect of p53 inhibition in multipotent pancreatic progenitor cells (MPCs) on the generation of PDX1+/NKX6.1+ MPCs and pancreatic β-cell generation.
[Stem Cell Reviews and Reports] |
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| Scientists observed that Fam122a deficiency impaired mesendodermal specification and cardiac differentiation from mESCs but showed no influence on pluripotent identity.
[Stem Cells] |
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| Researchers addressed H2A-deubiquitinases functions in epigenetic regulation of mammalian development and tissue maintenance by conducting a meta-analysis of 248 genomics datasets from 32 independent studies, focusing on the mouse model and covering ESCs, hematopoietic, and immune cell lineages.
[International Journal Of Biochemistry & Cell Biology] |
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| ESC lines were treated with the ALK-5 inhibitor SB431542; HADC100 cells were additionally treated with ALK-5 inhibitors SB525334 or GW788388. Cells were then seeded upon human fibronectin in the presence of fibroblast growth factor 2 in a serum-free medium.
[Tissue Engineering Part A] |
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| The expression of chromoboxes (CBXs) in cancers and the relationship between CBXs and clinical characteristics are prognosis were discussed.
[International Journal Of Oncology] |
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| The science committee of Indonesia’s Parliament is calling on the nation’s president to fire the head of its embattled research agency, following extensive controversy over the government’s efforts to consolidate research programs under the National Research and Innovation Agency.
[ScienceInsider] |
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| April 23 – 26, 2023
Paris, France |
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| | STEMCELL Technologies, Inc. – Cambridge, England, United Kingdom |
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| | Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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| | Lund University- Lund, Sweden |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | European Molecular Biology Laboratory – Barcelona, Spain |
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