 | | Vol. 18.06 – 15 February, 2023 |
| |
|
|
| To advance the understanding of mechanisms restricting the expression of germline genes, scientists analyzed the chromatin signature in those genes and performed a CRISPR-Cas9 knock-out screen for genes involved in germline gene repression using a Dazl-GFP reporter system in mESCs.
[Nucleic Acids Research] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Through exact transcription start site mapping, researchers reported an evolutionarily conserved BTB domain-containing zinc finger protein, ZBTB12, as a molecular barrier for dedifferentiation of hPSCs.
[Nature Communications] |
|
|
|
| Investigators reported the direct derivation of human expanded potential stem cells (hEPSC) from human pre-implantation embryos. Like hEPSC, embryo-derived hEPSC exhibited a transcriptome similar to morula, comparable differentiation potency, and high genome editing efficiency.
[Advanced Science] |
|
|
|
| Scientists generated an inexpensive molecule-responsive differentiation-inducing chimeric antigen receptor that could activate Wnt3a signaling.
[Inflammation and Regeneration] |
|
|
|
| The authors generated a cellular model that recapitulated neurogenesis defects observed in patients with Alzheimer’s disease (AD), using iPSC lines derived from sporadic and familial AD.
[Stem Cell Reports] |
|
|
|
| Investigators identified and characterized extreme long-range interactions of the Oct4 distal enhancer through a novel CRISPR labeling technique that they had developed.
[Cell Death Discovery] |
|
|
|
| Researchers revealed the developmental trajectory of middle cell layer initiation and maintenance in callus originating from Arabidopsis thaliana hypocotyls.
[Development] |
|
|
|
| The authors demonstrated that mESCs when cultured continuously, with inhibition of PKC, for 75 days were retained in naïve state of pluripotency.
[Stem Cell Reviews and Reports] |
|
|
|
| Scientists showed that SOX15 contributed to stem cell maintenance by cooperating with ESC-enriched transcriptional coactivators to ensure optimal expression of pluripotency-associated genes.
[Journal of Biological Chemistry] |
|
|
|
|
| Investigators highlight recent research and current challenges in hPSC modeling of brain and neural crest neoplasms, and conclude with a call for more rigorous quality control and for the development of models for rare tumor subtypes.
[Neuro-Oncology] |
|
|
|
| The authors review opportunities and limitations for studying psychiatric disorders using various hiPSC-derived model systems.
[Molecular Psychiatry] |
|
|
|
|
| Drs. Della David and Peter Rugg-Gunn from the Babraham Institute were awarded Wellcome Discovery Awards in the round of awards made at the end of 2022. They will pursue bold and ambitious research projects, pushing the boundaries of our knowledge of fundamental biology.
[Babraham Institute] |
|
|
|
|
| April 24 – 25, 2023
Cambridge, Massachusetts, United States |
|
|
|
|
|
| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
|
|
|
| | Kunming University of Science and Technology – Kunming, China |
|
|
|
| | Paracelsus Medical University – Salzburg, Austria |
|
|
|
| | STEMCELL Technologies, Inc. – Cambridge, England, United Kingdom |
|
|
|
| | Weill Cornell Graduate School of Medical Sciences – New York, New York, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
