 | | Vol. 18.07 – 22 February, 2023 |
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| Scientists created iPSCs from two species of bats: the wild greater horseshoe bat and the greater mouse-eared bat. The iPSCs from both bat species showed similar characteristics and had a gene expression profile resembling that of cells attacked by viruses.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators developed an accurate mass spectrometry-based proteomic method called chromatin aggregation capture followed by data-independent acquisition and analyzed chromatome reorganizations during major phases of pluripotency.
[Nucleic Acids Research] |
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| Guided by the genetic lesions that have been associated with alternative lengthening of telomeres (ALT) from cancer sequencing studies, researchers genetically engineered primary hPSCs to deterministically induce ALT upon differentiation.
[Nature Communications] |
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| The authors showed that upon SMCHD1 ablation, double homeobox 4 (DUX4) became derepressed in H9 hESCs as they differentiated toward a placode cell fate, triggering cell death.
[Science Advances] |
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| Investigators reported that simultaneous overexpression of two transcription factors could direct the differentiation of hiPSCs to granulosa-like cells.
[Elife] |
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| Researchers investigated a recurrent abnormality found on amniocentesis, the isochromosome 20q (iso20q), during a clinical retinal pigment epithelium differentiation. They showed that the iso20q abnormality interrupted spontaneous embryonic lineage specification.
[Stem Cell Reports] |
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| To test whether differences in cellular growth rates might reflect the clinical observations in attention-deficit hyperactivity disorder (ADHD) patients, scientists analyzed the proliferation of iPSCs and neural stem cells derived from male children and adolescents diagnosed with ADHD and with genetic predisposition to it.
[Journal of Neural Transmission] |
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| Immunomodulatory effect of transduced iPSCs with expression of Decorin (Dcn) gene on allergic asthma pathophysiology was evaluated. After transduction of iPSCs with Dcn gene, allergic asthma mice were treated with iPSCs and transduced iPSCs via intrabronchial route.
[Journal of Investigative Medicine] |
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| As the first phase of differentiation, embryoid bodies were formed from iPSCs. They were then cultured in different dynamic conditions in order to determine the appropriate settings for their differentiation into hematopoietic stem cells.
[Tissue and Cell] |
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| The authors describe pioneering studies of cell competition across a variety of cellular contexts and organisms, with the ultimate goal of better understanding competition in mammalian stem cells.
[Cell Death & Differentiation] |
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| Ryne Biotechnology, Inc. announced that the California Institute for Regenerative Medicine has awarded the company a $4 million Clinical Stage Research Program grant.
[Ryne Biotechnology, Inc.] |
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| April 24 – 25, 2023
Cambridge, Massachusetts, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | Paracelsus Medical University – Salzburg, Austria |
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| | Kunming University of Science and Technology – Kunming, China |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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Cancer Stem Cell News
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