 | | Vol. 18.08 – 1 March, 2023 |
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| Investigators reported the identification of 979 proteins acylated with O-linked β-N-acetylglucosamine (O-GlcNAc) and 1,340 modification sites in mESCs by using a chemoproteomics method.
[Angewandte Chemie-International Edition] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| To study development toxicity of tetrabromobisphenol A, the proliferation toxicity was investigated using hESCs exposed to the lowest effective dose of two tetrabromobisphenol A analogs.
[Journal of Hazardous Materials] |
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| Researchers profiled the transcriptomes, nucleosome positioning, and key histone modifications of four mouse haploid ESC lines, and compared these profiles with those of other closely-related stem cell lines, MII oocytes, round spermatids, sperm, and mouse embryonic fibroblasts.
[Cell Proliferation] |
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| The effects of bone morphogenetic protein (BMP) and Wnt signaling on the differentiation of SAN-like pacemaker cells were investigated. hiPSCs were divided into four groups: control, BMP4, CHIR—3, and BMP4 + CHIR.
[Cell Biology and Toxicology] |
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| Scientists established a culture system that induced a robust number of primordial germ cell-like cells from common marmoset ESCs.
[Scientific Reports] |
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| Chemical reprogramming was induced according to the gene expression pattern of extra-embryonic endoderm (XEN) cells, which were used as an intermediate stage in pluripotency induction.
[Molecules and Cells] |
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| Researchers showed that electroporation was an effective gene delivery method with which lymphoblastoid cell lines could be efficiently reprogrammed into iPSCs.
[International Journal Of Stem Cells] |
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| Scientists investigated the role of DNA methyltransferases (Dnmt) in neural differentiation of ESCs and in maintenance of the resulting neural stem cells. They used three types of Dnmt knockout (KO) ESCs, including Dnmt1 KO, Dnmt3a/3b double KO, and Dnmt1/3a/3b triple KO.
[International Journal Of Stem Cells] |
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| The morphology, pluripotent marker expression, and differentiation ability of bovine bESCs cultured on low-density, or methanol-fixed mouse embryonic fibroblasts were examined by immunofluorescent staining, Western blotting, real-time reverse transcription polymerase chain reaction, and RNA-seq.
[In Vitro Cellular & Developmental Biology – Animal] |
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| The authors discuss the current advances in cell replacement therapy for Parkinson’s disease and summarize the existing experimental and clinical evidence supporting this approach.
[Europe Pmc] |
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| On 13th of February, a transplant of stem cell-derived nerve cells was administered to a person with Parkinson’s at Skåne University Hospital, Sweden. The product has been developed by Lund University and it is now being tested in patients for the first time.
[Lund University] |
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| March 26 – 29, 2023
Snowbird, Utah, United States |
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| | University of Luxembourg – Esch-sur-Alzette, Luxembourg |
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| | The Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus – Frankfurt, Germany |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | Paracelsus Medical University – Salzburg, Austria |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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