 | | Vol. 18.09 – 8 March, 2023 |
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| Scientists generated pulmonary ionocytes from normal and cystic fibrosis human induced pluripotent stem cells.
[American Journal of Respiratory and Critical Care Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers evaluated the impact of MLL3/4 loss on chromatin and transcription during early differentiation of mESCs. They found that MLL3/4 activity was required at most if not all sites that gained or lost H3K4me1 but was largely dispensable at sites that remained stably methylated during this transition.
[Genome Biology] |
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| The authors demonstrated that transcriptional repression exerted by Wnt/TCF7L1 promoted primitive endoderm differentiation of mESCs and in preimplantation inner cell mass.
[Nature Communications] |
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| Investigators showed precise correction of two ABCA4 pathogenic variants in hiPSCs from two unrelated patients affected with Stargardt disease. Gene editing was achieved with no detectable off-target genomic alterations.
[Molecular Therapy – Nucleic Acids] |
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| Scientists reported that the reactivation of transposable elements upon SETDB1 knockout was responsible for the RIPK3 regulation through both cis and trans mechanisms.
[Cell Death & Disease] |
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| Researchers hypothesized that pluripotent, endogenous, tissue-resident, very small embryonic-like stem cells that existed in small numbers in all adult tissues, exited from their quiescent state due to epigenetic changes in response to various insults and transformed into cancer stem cells to initiate cancer.
[Stem Cells] |
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| After expression levels of nicotinic acetylcholine receptor (nAChR) subunits in hiPSCs were determined, the effects of the nAChR agonist, nicotine, on undifferentiated hiPSCs were evaluated using a Clariom S Array. Investigators also determined the effect of nicotine alone and with a nAChR subunit antagonist on hiPSC cells.
[Stem Cells and Development] |
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| The Health and Environmental Sciences Institute Cell Therapy-TRAcking, Circulation, and Safety Technical Committee launched an international, multisite study to evaluate the sensitivity and reproducibility of the highly efficient culture assay, an in vitro assay to detect residual undifferentiated hPSCs in cell therapy products.
[Regenerative Medicine] |
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| Scientists elucidated the role of the TGF-β signaling pathway in PeNK6 through adding small molecule inhibitors, SB431542 or A83-01, into the original culture medium and analyzing the expression and activity of key factors involved in the TGF-β signaling pathway.
[In Vitro Cellular & Developmental Biology – Animal] |
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| In the context of immune rejection, there are several modes of stem cell-based therapies. The authors discuss several practical points of stem cell-based therapies for Parkinson’s disease.
[Inflammation and Regeneration] |
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| Researchers in the United Kingdom (UK) breathed a cautious sigh of relief after the government struck a deal with the European Union (EU) to fix post-Brexit disputes over issues including trade across Northern Ireland’s border.
[ScienceInsider] |
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| April 30 – May 5, 2023
Barga, Italy |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Yale School of Medicine – New Haven, Connecticut, United States |
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| | Rutgers Biomedical and Health Sciences – New Brunswick, New Jersey, United States |
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| | University of Luxembourg – Esch-sur-Alzette, Luxembourg |
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| | Francis Crick Institute – London, England, United Kingdom |
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Cancer Stem Cell News
Cell Therapy News
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ESC & iPSC News
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Neural Cell News
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