 | | Vol. 18.10 – 15 March, 2023 |
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| Researchers efficiently converted the XY chromosome set to XX without an additional Y chromosome in mPSCs.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators employed hPSCs with thousands of randomly integrated barcoded reporters to assess epigenetic features that influenced CRISPRa efficacy. Basal expression levels were influenced by genomic context and dramatically changed during differentiation to neurons.
[Molecular Cell] |
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| Mechanistically, scientists showed that antigen-independent CAR signaling during lymphoid development enriched for innate lymphoid cell 2 (ILC2)-primed precursors at the expense of T cell precursors.
[Cell Reports] |
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| The authors revealed the developmental trajectory of middle cell layer initiation and maintenance in callus tissue originating from Arabidopsis thaliana hypocotyls.
[Development] |
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| Researchers used nano differential scanning fluorimetry, a label and immobilization-free assay, to demonstrate that an equimolar ratio of Cas9 and guide RNA was optimal.
[iScience] |
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| Scientists reported an approach to improve cell penetration depth of hiPSCs in 3D scaffolds modified with hiPSCs conditioned medium.
[Macromolecular Bioscience] |
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| The authors asked if secreted frizzled related protein 2 (Sfrp2) would drive the differentiation of human iPSCs into cardiomyocytes. They found that Sfrp2 induced robust cardiac differentiation.
[Scientific Reports] |
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| Investigators highlight the superiority of lymphocyte-origin cells over ESCs in functional immune cell differentiation.
[Biochemical and Biophysical Research Communications] |
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| An iPSC line was generated started from peripheral blood mononuclear cells from a patient carrying a homozygous variant in the IPO8 gene.
[Stem Cell Research] |
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| The authors give a succinct overview of lipid peroxidation and discuss the major players in the ferroptotic cascade. They also discuss the important role of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway in mediating lipid peroxidation and ferroptosis.
[Cellular Signalling] |
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| Regarding pluripotent stem cells, expression of bonafide marker proteins such as Oct4, Nanog, Sox2, Klf4, c-Myc, and Lin28 have been considered giving a perfect readout for pluripotent stem cells and assessed using an analytical flow cytometer.
[Cytometry Part A] |
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| Researchers from the University of Sydney have been awarded $47 million to support 32 research projects, including investigations of younger-onset dementia, the treatment of blinding eye diseases through stem cell therapy, and the impact of e-cigarette use by adolescents.
[The University of Sydney] |
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| May 15 – 19, 2023
Whistler, British Columbia, Canada |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | UCSF Diabetes Center – San Francisco, California, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | Yale School of Medicine – New Haven, Connecticut, United States |
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