 | | Vol. 18.11 – 22 March, 2023 |
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| By screening for small molecule boosters and systematically optimizing the original condition, scientists established a robust, chemically defined reprogramming protocol, which greatly shortened the induction time and enabled highly reproducible and efficient generation of human somatic cells to PSCs.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers analyzed the endogenous Sox2 locus using Big-IN to scarlessly integrate large DNA payloads incorporating deletions, rearrangements, and inversions affecting single or multiple DNase I hypersensitive sites, as well as surgical alterations to transcription factor recognition sequences.
[Molecular Cell] |
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| Investigators showed that enzymes that catalyze H3K9 methylation, such as Suv39h1, Suv39h2, G9a, and Glp, were also retained on mitotic chromosomes.
[Nature Structural & Molecular Biology] |
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| The authors established a foundation for in vitro oogenesis in cynomolgus (cy) monkeys: cy female ESCs harboring one active and one inactive X chromosome differentiated robustly into primordial germ cell-like cells, which in xenogeneic reconstituted ovaries developed into oogonia and, further into meiotic oocytes.
[EMBO Journal] |
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| Adult and neonatal human fibroblasts were treated with hydralazine and/or valproic acid, and viability and gene expression assays for OCT4, NANOG, c-MYC, KLF4, DNMT1, TET3, ARID1A, and ARID2 by quantitative PCR were performed.
[Stem Cell Research & Therapy] |
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| Researchers reported that mESCs could efficiently prevent unscheduled R-loop formation, and a long noncoding RNA Lnc530 played a regulatory role.
[Stem Cell Reports] |
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| Scientists reported scalable fabrication of 2i-functionalized micro-pyramid-array inserts for use in commercial multiwell plates, as the alternative cultivation platform for maintaining long-term self-renewal and pluripotency of multiple mESCs and miPSCs.
[iScience] |
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| Investigators observed that cell growth was ideally maintained by factors such as optimal acceleration, aggregate formation, and cell death.
[Journal of Bioscience and Bioengineering] |
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| The authors examine lymphoid development from non-hematopoietic stem cell progenitor cells and technological advances in the differentiation of human lymphoid cells from PSCs for clinical translation.
[Immunological Reviews] |
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| The University System of Georgia Board of Regents approved two University of Georgia professors, Steven Stice and Biao He, as Regents’ Entrepreneurs. The distinction recognizes faculty who have demonstrated success in translating research into a commercial setting.
[University of Georgia] |
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| | University of Exeter – Exeter, England, United Kingdom |
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| | Ariel University – Ariel, West Bank |
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| | Columbia University – New York, New York, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | UCSF Diabetes Center – San Francisco, California, United States |
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