 | | Vol. 18.12 – 29 March, 2023 |
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| Researchers revealed that the competence for the future cardiac fate of hESCs was preset in pluripotency by a specialized mRNA translation circuit controlled by RNA binding protein with multiple splicing.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| hiPSCs were generated from somatic cells by transduction of 4 human transcription factors using Sendai virus vectors. Genome-wide DNA methylation analysis and transcriptional analysis were performed to evaluate the pluripotent capacity and somatic memory state of hiPSCs.
[Arteriosclerosis Thrombosis And Vascular Biology] |
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| Researchers showed the generation of thymic epithelial cells in vitro in isogenic stem cell-derived thymic organoids, consisting of thymic epithelial progenitors, hematopoietic progenitor cells, and mesenchymal cells, differentiated from the same hPSC line.
[Stem Cell Reports] |
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| Scientists generated hypothalamic neural stem cell-like cells from hESCs. They differentiated retina and anterior neural fold homeobox (RAX)::VENUS knockin hESCs into hypothalamic organoids and sorted RAX+ cells from mature organoids.
[Stem Cell Reports] |
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| Investigators generated a Rif1 conditional knockout mESC line based on Cre-loxP system. Western blot, flow cytometry, qRT-PCR, RNA-Seq, ChIP-Seq, ChIP-qPCR, immunofluorescence, and immunoprecipitation were employed for phenotype and molecular mechanism assessment.
[Stem Cell Reviews and Reports] |
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| The authors reported scalable fabrication of 2i-functionalized micro-pyramid-array inserts for use in commercial multiwell plates, as the alternative cultivation platform for maintaining long-term self-renewal and pluripotency of multiple mESCs and miPSCs.
[iScience] |
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| Researchers studied the effects of layered double hydroxide (LDH) without loaded factors on mESC neurogenesis. The enhanced differentiation of mESCs into motor neurons by LDH was systematically validated by immunofluorescent staining, qRT-PCR analysis, and western blot analysis.
[Biomedical Materials] |
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| Scientists investigated the relationship between gene expression levels and morphology by analyzing live-cell phase-contrast images and mRNA profiles collected during the purification process.
[Molecular Biology of the Cell] |
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| Investigators performed a comprehensive proteogenomics analysis of 190 genetically diverse mESC lines. The quantitative proteome was highly variable across lines, and they identified pluripotency-associated pathways that were differentially activated in the proteomics data.
[Cell Genomics] |
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| The authors discuss the function of miR-21 in regenerative medicine of the liver, nerve, spinal cord, wound, bone, and dental tissues. In addition, the function of natural compounds and lncRNAs was analyzed as potential regulators of miR-21 expression in regenerative medicine.
[Stem Cell Reviews and Reports] |
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| Roslin Technologies was presented with the Scottish Life Science Award for Innovation – Animal Health, Agritech, and Aquaculture
[Roslin Technologies] |
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| May 7 – 12, 2023
Barcelona, Spain |
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| | VIB-UAntwerp Center of Molecular Neurology – Antwerp, Belgium |
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| | University of Exeter – Exeter, England, United Kingdom |
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| | Ariel University – Ariel, West Bank |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | University of California San Francisco – San Francisco, California, United States |
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