 | | Vol. 18.13 – 5 April, 2023 |
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| Cell reprogramming-inspired dynamically responsive hydrogel was fabricated via a synthetic biology-based strategy. Human and mouse somatic cells had been efficiently reprogrammed into iPSCs that exhibited key features of ESCs.
[Advanced Materials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists used their individual Mitochondrial Genome sequencing technology to study mitochondrial DNA (mtDNA) heterogeneity, quantitate single nucleotide variants and large structural variants, track heteroplasmy dynamics, and analyze genetic linkage between variants at the individual mtDNA molecule level in single oocytes and human blastoids.
[Nucleic Acids Research] |
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| Researchers reported the first establishment of a hiPSC line from a patient with heterozygous high-temperature requirement serine peptidase A1 (HTRA1)-related cerebral small vessel disease.
[Inflammation and Regeneration] |
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| The authors investigated the role of crotonylation in hESC differentiation by introduce crotonate into the culture medium of GFP tagged LTR7 primed H9 cell and extended PSC lines.
[Stem Cell Research & Therapy] |
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| Investigators differentiated androgenetic and parthenogenetic hPSCs into ovarian granulosa-like cells (GLCs). They showed that in contrast to biparental and androgenetic cells, parthenogenetic hPSCs presented a reduced capacity to differentiate into GLCs.
[Stem Cell Reports] |
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| Researchers showed that static magnetic fields (SMFs) promoted the expression of the core pluripotent markers Sox2 and SSEA-1. Furthermore, SMFs facilitated the differentiation of ESCs into cardiomyocytes and skeletal muscle cells.
[Stem Cell Reviews and Reports] |
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| Scientists developed an hiPSC-based model to study the effect of collective cell migration in meso–endodermal lineage segregation and cell fate decisions through the control of space confinement using a detachable ring culture system.
[Journal of Biological Engineering] |
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| Investigators generated a Upf3a conditional knockout mouse strain and established multiple lines of ESCs and somatic cells without UPF3A. UPF3A neither repressed nonsense-mediated mRNA decay in mouse ESCs, somatic cells, nor in major organs including the liver, spleen, and thymus.
[Life Science Alliance] |
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| Researchers reported a crystal structure of ZBTB7A zinc finger (ZF) 1–3 in complex with the primed-to-naïve transition (PNT) associated sequence.
[FEBS Journal] |
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| The authors summarize the development of extracellular matrix proteins for hPSCs, which are now the mainstream alternative, and synthetic substrates which are expected to be the future mainstream alternative.
[Biomaterials Science] |
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| A team of scientists led by a Northumbria University academic has won funding from the Academy of Medical Sciences’ Springboard scheme to research age-related macular degeneration, a disease suffered by over 190 million people worldwide.
[Northumbria University, Newcastle] |
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| May 16 – 17, 2023
Aachen, Germany |
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| | STEMCELL Technologies Inc. – Vancouver, British Columbia, Canada |
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| | Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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| | The University of Utah – Salt Lake City, Utah, United States |
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| | King’s College London – London, England, United Kingdom |
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| | VIB-UAntwerp Center of Molecular Neurology – Antwerp, Belgium |
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