 | | Vol. 18.15 – 19 April, 2023 |
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| Using expansion microscopy, researchers found striking changes in heparan sulfate nanostructure occured as human pluripotent stem cells differentiate, and these changes correlated with growth factor signaling.
[ACS Nano] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors identified a gene set of 118 genes commonly dysregulated in all patient enteric neural crest cells, and suggested HDAC1 may be a key regulator of these genes.
[Nature Communications] |
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| Scientists uncovered a homozygous p.Thr543Met variant segregating with a neonatal lethal syndrome with cutaneous, craniofacial, cardiac, and limb anomalies.
[EMBO Molecular Medicine] |
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| The authors induced human ESCs as endothelial cell (EC) lineage and produced high-purity ECs through fluorescence-activated cell sorting.
[Advanced Healthcare Materials] |
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| Investigators showed that mouse ESCs solely exposed to chemical inhibition of SUMOylation generate embryo-like structures comprising anterior neural and trunk-associated regions.
[Cell Reports] |
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| Researchers presented the generation and characterization of astrocytes from human ESCs with the characteristics of the ventral midbrain.
[Stem Cell Reviews And Reports] |
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| After a CRISPR/Cas9-based functional genomics screen and integrative analysis with other functional genomes, transcriptomes, proteomes and epigenome data, an expanded pluripotency-associated gene set was obtained, and a new pluripotency gene regulatory network with nine sub-classes was constructed.
[Communications Biology] |
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| Investigators determined the role of miR-146a in vascular smooth muscle cell (VSMC) differentiation from ESCs. Mouse ESCs were differentiated into VSMCs, and the cell extracts were analyzed by Western blotting and RT-qPCR.
[Current Medical Science] |
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| CRISPR-Cas9-based functional genomics screening offered a powerful approach to determine gene function in a high-throughput manner. With the maturation of stem cell technology, a variety of human cell types could be derived from human PSCs.
[Cell Genomics] |
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| Investigators present a thorough review of the characteristics, functions, and clinical importance of MSCs. The existing sources of MSCs, including adult- and infant-based sources, are compared.
[Biomaterials Research] |
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| The authors discuss their applications in studies of regulatory mechanisms involved in early developmental processes, including identification of molecular features, X chromosome inactivation modeling, transposable elements regulation, metabolic characteristics, and cell fate regulation.
[Cell Reports] |
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| The Sanford Stem Cell Institute at UC San Diego has announced the launch of a collaborative Astrobiotechnology Hub to further advance space stem cell and molecular research in a new realm.
[The Guardian] |
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| The SIMPATHIC Consortium, led by the Radboud University Medical Center and Amsterdam UMC, has developed a new approach to expedite the use of existing drugs for groups of patients with rare neurological disorders.
[Amsterdam UMC] |
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| May 23 – 25, 2023
Bar Harbor, Maine, United States & Virtual |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Universit̩ de Lausanne РLausanne, Switzerland |
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| | STEMCELL Technologies Inc. – Vancouver, British Columbia, Canada |
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| | Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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| | The University of Utah – Salt Lake City, Utah, United States |
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