 | | Vol. 18.16 – 26 April, 2023 |
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| Investigators applied FLIM-FRET microscopy to analyze, in living cells, the spatial organisation of nanometre range proximity between nucleosomes, which they called “nanocompaction.”
[EMBO Journal] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using mouse ESCs with an inducible knockout of Oct1, the authors showed that Oct1 deficiency resulted in poor induction of mesoderm-specific genes, leading to impaired mesodermal and terminal muscle differentiation.
[Science Signaling] |
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| Researchers defined a specific dynamic 3D manufacturing system in a baffled-flow manner that could remarkably facilitate megakaryopoiesis and increase the yield of platelet-producing megakaryocyte from hESCs within a 12-day induction period.
[Cell Proliferation] |
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| To identify the genes and pathways that confered resistance to frontline cancer therapies, investigators performed a genome-wide screen in haploid human ESCs.
[Cell Proliferation] |
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| The authors performed a detailed electrophysiological analysis related to the functioning of these channels in human ESC-derived retinal pigment epithelium.
[BMC Biology] |
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| Scientists aimed to restore a disease mutation in a patient with severe hemophilia B using base editing with SpCas9-NG, a modified Cas9 with the board PAM flexibility.
[Communications Biology] |
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| To understand the physiological relevance of the phosphorylation on Bcl11b protein, the authors replaced serine/threonine residues with alanine by targeting murine Bcl11b gene in ESCs.
[Journal Of Immunology] |
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| Scientists developed an iPSC-based global epigenetic modulation detection assay using hiPSCs that express a fluorescently labeled methyl-CpG-binding domain, which enabled a high-throughput screening of epigenetic teratogens/mutagens.
[Scientific Reports] |
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| The authors presented MitoTNT, the first-in-class software for Mitochondrial Temporal Network Tracking in 4D live-cell fluorescence microscopy data. MitoTNT used spatial proximity and network topology to compute an optimal tracking assignment.
[PLOS Computational Biology] |
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| Scientists identify barriers to canine somatic cell reprogramming on molecular and cellular levels, using comparative research to inform potential solutions to their use in both research and clinical contexts.
[Stem Cells And Development] |
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| Transferring the knowledge gained from human iPSCs can increase our understanding in the biology of pluripotent cells in animals, but it is critical to further investigate the differences among species to develop specific approaches for animal iPSCs.
[Frontiers In Veterinary Science] |
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| The Tisch MS Research Center of New York announced the Phase II results of its FDA-approved stem cell treatment study. The research is a continuation of a Phase I trial, which was the first ever in the US to receive FDA approval to investigate the injection of stem cells into the cerebrospinal fluid of MS patients.
[The Tisch MS Research Center of New York (BusinessWire, Inc.)] |
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| The Icahn School of Medicine at Mount Sinai announced the creation of the Institute for Regenerative Medicine to foster innovative research into new pathways to cure a host of diseases from leukemia to Alzheimer’s disease, breast cancer, and airway diseases
[Mountain Sinai] |
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| It may seem like a galaxy far, far away when human beings from earth can stay for a long period of time in a spacecraft or even on the moon or Mars, but Malaysian scientist Prof Dr Kee Keh Kooi has already begun research on its effects on human bodies.
[The Star] |
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| May 23 – 25, 2023
Bar Harbor, Maine, United States & Virtual |
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| | The Human Technopole Foundation – Milan, Italy |
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| | CT19 Ltd. – London, England, United Kingdom |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | STEMCELL Technologies Inc. – Vancouver, British Columbia, Canada |
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