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Investigators found that critically short telomeres altered retrotransposon activity to promote genomic instability in mouse ESCs, as evidenced by elevated numbers of single nucleotide variants, indels and copy number variations
[Cell Discovery] |
|  | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors used murine embryonic stem cell models to show that ESRRB was both required and sufficient to activate formative genes.
[Nature Cell Biology] |
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| Researchers showed that desert lncRNAs were highly expressed with cell-stage-specific patterns and conserved subcellular localization during stem cell differentiation.
[Genome Biology] |
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| The authors used scRNA-seq to discover a population of CD31− CD45− cells in the stromal vascular fraction that were distinguished by a specific expression profile.
[Cell Reports] |
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| 3D-printed barium-doped calcium silicate/poly-ε-caprolactone composite scaffolds were fabricated as an alternative strategy for bone tissue engineering to achieve appropriate physicochemical characteristics and stimulate osteogenesis.
[Journal Of Materials Chemistry B] |
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| The authors enhanced the CRISPaint system by introducing new universal donors for N-terminal insertion and for multi-color tagging with orthogonal selection markers.
[Development] |
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| Scientists illustrate the use of iPSCs as platforms for investigating cardiomyocyte phenotypes in a human family pedigree exemplified by novel heterozygous RYR2-A1855D and SCN10A-Q1362H variants occurring alone and in combination.
[Philosophical Transactions Of The Royal Society B-Biological Sciences] |
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| Investigators derived and characterized 15 iPSC lines from four Saudi 47,XXY KS patients and one Saudi 46,XY male. They performed a comparative transcriptional analysis using the Saudi KS-iPSCs and a cohort of European and North American KS-iPSCs.
[Endocrine Connections] |
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| The authors provide an overview of the generation of human cortical organoids and the properties of recapitulated cortical development and further outline their applications in modeling malformations of cortical development including pathological phenotype, underlying mechanisms and rescue strategies.
[Neural Regeneration Research] |
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| Researchers at the University of Manitoba (UM) and the Children’s Hospital Research Institute of Manitoba have been awarded $250,000 over two years to advance cutting-edge 3D bioprinting technology to create patient-specific heart models of those living with rare genetic diseases.
[University of Manitoba] |
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| June 2 – 6, 2023
Chicago, Illinois, United States |
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| | University Hospital Carl Gustav Carus Dresden – Dresden, Germany |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| The Human Technopole Foundation – Milan, Italy |
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