 | | Vol. 18.18 – 10 May, 2023 |
| |
|
|
| Researchers generated mouse and human hypoimmune pluripotent stem cells by depleting HLA class I and II molecules and overexpressing CD47.
[Nature Biotechnology] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| The authors presented a strategy for deriving Schwann cells (SCs) from hPSCs that enabled comprehensive studies of SC development, physiology, and disease.
[Cell Stem Cell] |
|
|
|
| Investigators applied single-cell RNA sequencing to profile transcriptional cell states of the acoel worm Hofstenia miamia during postembryonic development and regeneration.
[Nature Communications] |
|
|
|
| The authors reported that a chemical cocktail, previously developed for extended PSCs in mice and humans, enabled de novo derivation and long-term culture of bovine trophoblast stem cells.
[Cell Reports] |
|
|
|
|
Scientists showed that a first-generation recombinant adeno-associated virus (rAAV)-ST3GAL5 replacement vector using a ubiquitous promoter restored tissue ST3GAL5 expression and normalized cerebral gangliosides in patient-derived induced PSC neurons and brain tissue from St3gal5-KO mice.
[JCI Insight] |
| | Researchers showed that overexpression of an antiapoptosis gene, BCL2, in haploid ESCs robustly ensures their haploidy maintenance in various situations, even under strict differentiation in vivo.
[Cell Proliferation] |
|
|
|
| Researchers presented spatial transcriptomics analysis of fully differentiated grafts in their host tissue. They observed that cells derived from human embryonic stem cells (hESC) in the grafts adopted mature dopaminergic signatures.
[Molecular Therapy-Methods & Clinical Development] |
|
|
|
| Researchers presented protocols to illustrate the methods for conducting small-molecule-mediated differentiations of hiPSCs into cardiomyocytes, endothelial cells, and cardiac fibroblasts, as well as to assemble the fully integrated cardiac spheroids.
[Current Protocols] |
|
|
|
| The authors attempted to induce tenogenesis using stable Scleraxis (Scx) overexpression in combination with uniaxial mechanical stretch of iPSC-derived mesenchymal stromal-like cells.
[Journal Of Orthopaedic Research] |
|
|
|
|
|
|
The authors provide an overview of the achievements and challenges in using hPSC-derived organoids to conduct relevant high-throughput, high-contentscreens and drug evaluation.
[Cell Stem Cell] |
| | During neural differentiation, RNA guanine-7 methyltransferase (RNMT) was repressed and CMTR1 was up-regulated. RNMT promoted expression of the pluripotency-associated gene products; repression of the RNMT complex was required for repression of these RNAs and proteins during differentiation.
[Biochemical Society Transactions] |
| |
|
|
| Outside the Third International Summit on Human Genome Editing, protesters held banners that read “Stop designer babies” and “Never again to eugenics”, calling for a ban on human genome editing. It was a reminder of the ethical quandaries that embryo science and genome editing can present.
[Nature News] |
|
|
|
| When neuropsychologist Bernhard Sabel put his new fake-paper detector to work, he was “shocked” by what it found. After screening some 5000 papers, he estimates up to 34% of neuroscience papers published in 2020 were likely made up or plagiarized.
[Science Insider] |
|
|
|
|
|
June 18 – 22, 2023
Keystone, Colorado, United States |
| |
|
|
|
| | University of Western Australia – Perth, Australia |
|
|
|
| | Weill Cornell Medical College – New York, New York, United States |
|
|
|
| | Roche Institute of Translational Bioengineering – Zurich, Switzerland |
|
|
|
| | University Hospital Carl Gustav Carus Dresden – Dresden, Germany |
|
|
|
| | University of Cambridge – Cambridge, England, United Kingdom |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
