 | | Vol. 18.19 – 17 May, 2023 |
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| Researchers utilized high-efficiency reprogramming in microfluidics and temporal multi-omics to identify and resolve distinct sub-populations and their interactions.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators described a protocol to generate organoids with both forebrain entities called optic vesicles-containing brain organoids. They first induced neural differentiation and collect neurospheres, which they cultured in a neurosphere medium to initiate their patterning and further self-assembly.
[Nature Protocols] |
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| Researchers reported the development of an optogenetic human iPSC system for TGF-β signaling and demonstrated its utility in directing differentiation into the smooth muscle, tenogenic, and chondrogenic lineages.
[Cell Reports] |
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| Scientists established an efficient induction system for exogenous gene-independent iPSCs under chemically defined culture condition previously used for generation of stable pig pre-gastrulation epiblast stem cells.
[Cell Proliferation] |
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| A nested case-control study was conducted in Northwest women’s and children’s Hospital, Xi’an, China. The patients underwent fresh IVF/ICSI cycles with single blastocyst transfer were included. Total 78 cases were included and separated into groups according to success and failure implantation outcomes.
[Heliyon] |
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| Inoculation of iPSCs-podocytes significantly promoted the repair of kidney injury in acute kidney injury mice, reduced the levels of kidney injury factors Scr, BUN, and urinary NAG, and alleviated the inflammatory response.
[Chemico-Biological Interactions] |
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| Differentiation to excitatory neurons with subsequent characterization by transcriptomics and cell surface proteomics identified deletion-associated alterations in proliferation and adhesion.
[Scientific Reports] |
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| Researchers determined whether p66Shc could act as a negative regulator of extracellular signal regulated kinase (ERK) activity during embryonic development, antagonizing early lineage commitment.
[Stem Cells and Development] |
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| Parallel genome-wide CRISPR/Cas9 knockout screens were applied in ESCs cultured in the serum plus LIF and in the 2i plus LIF conditions. The candidate genes were classified into seven groups based on their positive or negative effects on self-renewal.
[Stem Cells and Development] |
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| Investigators detail the importance of CRISPR/Cas9-based stem cell therapy in Parkinson’s disease (PD) in developing PD disease models and developing therapeutic strategies.
[Biomaterials Research] |
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| The Maryland Stem Cell Research Fund Commission has announced over $14.1 million in grant awards to promote innovative research that will strengthen and advance stem cell treatments and technologies in Maryland.
[TEDCO] |
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| June 2 – 6, 2023
Chicago, Illinois, United States |
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| | Massachusetts Institute of Technology – Cambridge, Massachusetts, United States |
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| | DFG Research Training Group – Berlin, Germany |
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| | Center for Disease Neurogenomics at the Icahn School of Medicine – Manhattan, New York, United States |
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| | University of Western Australia – Perth, Australia |
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| | Weill Cornell Medical College – New York, New York, United States |
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