 | | Vol. 18.20 – 24 May, 2023 |
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| The authors showed that X-chromosomal transcripts had fewer m6A modifications and were more stable than their autosomal counterparts.
[Nature Structural & Molecular Biology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported that USP7 maintains mESC identity through both catalytic activity–dependent and –independent repression of lineage differentiation genes. Usp7 depletion attenuated SOX2 levels and derepresses lineage differentiation genes thereby compromising mESC pluripotency.
[Science Advances] |
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| Investigators showed that ERK activity duration or amplitude or the type of ERK dynamics alone did not influence exit from pluripotency, but the sum of activity over time did.
[Developmental Cell] |
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| Through homozygous knockout of MMR pathway key proteins MSH2, MSH3, and MSH6, scientists revealed that MutSα and MutSβ determined prime editor efficiency in an editing size-dependent manner.
[Molecular Therapy – Nucleic Acids] |
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| RNA-seq analyses of the human peri-implantation endometrium obtained from patients with recurrent implantation failure (RIF) and fertile controls revealed that PRC2 components were dysregulated in the RIF group.
[Cell Death & Disease] |
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| IPSCs were generated from 15 patients, differentiated into retinal organoids, and scored based on their retinal differentiation capacity. Despite significant differences in retinal differentiation propensity, RNA-sequencing revealed remarkable similarity between patient-derived iPSC lines prior to differentiation.
[Stem Cells Translational Medicine] |
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| The authors generated mouse ESC lines simultaneously expressing fluorescent reporters for ERK, AKT, and STAT3 signaling activity, which all control pluripotency.
[Stem Cell Reports] |
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| Researchers modulated WNT, Activin/Nodal, and MAPK signaling pathways by stage-specific addition of small molecule regulators CHIR99021, SB431542, and LY294002, respectively, and measured the impact on hematoendothelial formation in culture.
[Stem Cells] |
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| The combination of cells, bioink, and puromorphamine-releasing microspheres were used to mimic the in vivo environment and direct the differentiation of the neural progenitor cells into basal forebrain-resembling cholinergic neurons.
[Bioelectronic Medicine] |
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| Investigators discuss the strategies for achieving exact base edits in the creation of various stem cell-based models for use in elucidating disease mechanisms and assessing drug efficacy.
[CRISPR Journal] |
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| The world’s second-ever private astronaut mission to the International Space Station will not only ferry up the first Saudi Arabian woman to go to space but also a first-of-its-kind experiment that will test whether scientists can create induced pluripotent stem cells, or iPSCs, in microgravity.
[FierceBiotech] |
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| Rayyanah Barnawi, the first female Arab astronaut, has successfully arrived at the International Space Station as part of Axiom Space’s second private mission.
[The Free Press Journal] |
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| September 4 – 7, 2023
Surrey, England, United Kingdom |
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| | Virginia Tech – Washington, DC, United States |
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| | Massachusetts Institute of Technology – Cambridge, Massachusetts, United States |
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| | DFG Research Training Group – Berlin, Germany |
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| | Center for Disease Neurogenomics at the Icahn School of Medicine – Manhattan, New York, United States |
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| | University of Western Australia – Perth, Australia |
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