 | | Vol. 18.21 – 31 May, 2023 |
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| Researchers showed that GSK-3484862 targets DNMT1 for protein degradation in both cancer cell lines and murine ESCs. DNMT1 depletion was rapid, taking effect within hours following GSK-3484862 treatment, leading to global hypomethylation.
[NAR Cancer] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists uncovered apical-to-basal RNA asymmetries in outer blastomeres of 16-cell stage mouse preimplantation embryos. Basally directed RNA transport was facilitated in a microtubule- and lysosome-mediated manner.
[Nature Communications] |
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| Using notably lattice light-sheet microscopy, correlative light electron microscopy, and lineage assignment, investigators found that ~88% of cells lose centrioles during embryogenesis.
[Science Advances] |
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| The authors reported the generation and phenotypic characterization of Zc3h11a knockout mice. Heterozygous null Zc3h11a mice were born at the expected frequency without distinguishable phenotypic differences compared with wild-type mice.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators developed a mouse blood-brain barrier model, composed of mouse embryonic stem cell-derived brain endothelial-like cells, employing a directed monolayer differentiation strategy.
[Fluids And Barriers Of The CNS] |
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| By analyzing Pax2a and Nkx2.4b expression dynamics in relation to endodermal FGF and BMP signaling activities in zebrafish embryos, researchers identified a Pax2a-expressing thyroid progenitor population that shows enhanced FGF signaling but lacks Nkx2.4b expression and BMP signaling.
[Development] |
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| The authors identified a Notch activator and CYP modulator Valproic Acid, as a promotor for the maturation of iPSC-ent.
[Stem Cells] |
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| Scientists identified a function of cyclin F to regulate substrate solubility and showed how cyclin F mechanistically underlay amyotrophic lateral sclerosis and frontotemporal dementia disease pathogenesis.
[Molecular Neurobiology] |
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| Investigators highlight recent findings describing the dynamics and driving mechanisms for establishing 3D chromatin organization and discuss the role such organization has on gene regulation in early embryonic development.
[Current Opinion In Structural Biology] |
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| On the table was a nearly half-billion-dollar research plan to develop revolutionary stem cell and genetic treatments for afflictions ranging from cancer to heart disease. The proposed budget boosted spending by 41 percent for 2023-24 over expenditures for the current fiscal year.
[Capitol Weekly] |
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| Generative AI tools, including chatbots such as ChatGPT and image-generating software, provide new ways of producing paper-mill content, which could prove particularly difficult to detect.
[Nature News] |
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| July 16 – 21, 2023
Holderness, New Hampshire, United States |
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| | Babraham Institute – Cambridge, England, United Kingdom |
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| | University of California – Oakland, California, United States |
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| | University of Oxford – Oxford, England, United Kingdom |
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| | University of California – Oakland, California, United States |
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| | Babraham Institute – Cambridge, England, United Kingdom |
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