 | | Vol. 18.25 – 28 June, 2023 |
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| Scientists showed that human PSCs could be triggered to self-organize into three-dimensional structures that recapitulate some key spatiotemporal events of early human post-implantation embryonic development.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers combined two types of extraembryonic-like cells generated by transcription factor overexpression with wildtype embryonic stem cells and promoted their self-organization into structures that mimic several aspects of the post-implantation human embryo.
[Nature] |
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| Investigators defined the genome-wide occupancy and exchange pattern of canonical and non-canonical histone variants in mouse embryonic stem cells by genetically encoded exchange sensors.
[Nature Communications] |
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| To identify and elucidate the biological functions of rare variants underlying systemic lupus erythematosus (SLE), scientists conducted analyses of patient-derived iPSCs in combination with genetic analysis.
[Journal Of Autoimmunity] |
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| Researchers showed that hiPSCs can be differentiated into prostate organoids using neonatal rat seminal vesicle mesenchyme in vitro. The organoids could be used to study prostate development or modified to study prostate cancer.
[Development] |
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| The forced overexpression of CCAAT enhancer binding protein β (C/EBPβ) led to the downregulation of brachyury and a significant upregulation of the smooth muscle cell-related gene ACTA2 in ESCs.
[Biochemical And Biophysical Research Communications] |
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| Investigators introduced hiPSC-derived pericytes as a versatile and more uniform tool to study the pericyte-to-neuron conversion process.
[Cellular Reprogramming] |
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| A hiPSC line was generated from peripheral blood mononuclear cells isolated from a female with β-amyloid precursor protein (APP) gene mutation utilizing non-integrative Sendai virus.
[Stem Cell Research] |
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| Fibroblasts from two Parkinson’s disease patients carrying either the heterozygous mutation c.815G > A or c.1348C > T in the RHOT1 gene, were converted into iPSCs using RNA-based and episomal reprogramming, respectively.
[Stem Cell Research] |
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| Expression of the reprogramming factors that promote cellular reprogramming in vivo results in unique consequences that are not seen when cells are reprogrammed ex vivo, and can provide insights into development, tissue regeneration, cancer, and aging.
[Current Opinion In Genetics & Development] |
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| ONK Therapeutics, Ltd. announced that the European Patent Office granted its licensed patent covering CISH knockout in natural killer (NK) cells, irrespective of the source of the NK cells, including human cord blood-derived, peripheral blood-derived, and NK cells derived from iPSCs.
[ONK Therapeutics, Ltd.] |
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| July 18 – 20, 2023
Boston, Massachusetts, United States |
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| | The Buck Institute – San Francisco, California, United States |
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| | University College Dublin – Dublin, Leinster, Ireland |
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| | King’s College London – London, England, United Kingdom |
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| | University Hospital RWTH Aachen – Aachen, Germany |
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| | The University of California San Francisco – San Francisco, California, United States |
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