 | | Vol. 18.26 – 5 July, 2023 |
| |
|
|
| Investigators found that Zmym2−/− mice showed embryonic lethality by E10.5. Molecular characterization of Zmym2−/− embryos revealed two distinct defects.
[Nucleic Acids Research] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| The authors reported that protein arginine methyltransferase-1 (PRMT1)-mediated arginine 65 methylation of neurogenin 3 was required for the pancreatic endocrine development of hESCs in vitro.
[Experimental & Molecular Medicine] |
|
|
|
| Using a chemical genomic approach, scientists provided biological evidence that early germ layer fate decisions of hPSCs revealed targets of human cancers.
[Cell Chemical Biology] |
|
|
|
| Investigators combined optogenetic stimulation, imaging, and transcriptomic approaches to study self-organization of human ESCs in two-dimensional culture.
[Development] |
|
|
|
| Using dCas9-KRAB hPSCs, researchers demonstrated early inhibition of SIX1 alone significantly decreased PAX3 expression, reduced PAX7+ skeletal muscle progenitor cells, and myotubes later in differentiation.
[Development] |
|
|
|
| Using small-RNA sequencing, scientists characterized dynamic changes in miRNA expression profiles during outgrowth of inner cell masses in a high-resolution, time-course dependent manner.
[Stem Cell Reviews and Reports] |
|
|
|
| The authors uncovered that the FGF2-FGFR-ERK1/2 signaling contributed to mesendoderm and SOX17+ definitive endoderm (DE) formation. Without ERK1/2 signaling, the Activin/Nodal signaling was insufficient to drive mesendoderm and DE formation.
[iScience] |
|
|
|
| Scientists derived skin fibroblasts from a patient with acute myelitis (P-HAF) and then reprogrammed P-HAF cells to iPSC using eight exogenous factors.
[Frontiers In Cell And Developmental Biology] |
|
|
|
| Researchers applied CDKi within a specific time window, which improved the efficiency of pancreatic endocrine cell induction. CDKi treatment reduced the prevalence of multi-layered regions and enhanced expression of PDX1 and NGN3.
[In Vitro Cellular & Developmental Biology – Animal] |
|  |
|
|
|
| Owing to their manifold roles in health and disease, there have been intense efforts to synthetically generate blood vessels in vitro from hPSCs. The authors summarize how arterial or venous endothelial cells arise during embryonic development.
[Seminars in Cell & Developmental Biology] |
|
|
|
|
| The interdisciplinary team of Cathal Kearney, assistant professor of biomedical engineering, and Govind Srimathveeravalli, assistant professor in mechanical and industrial engineering, has received the 2023 Armstrong Fund for Science Award.
[University of Massachusetts Amherst] |
|
|
|
|
| September 17 – 20, 2023
Surrey, England, United Kingdom |
|
|
|
|
|
| | University of Southern Denmark – Odense, Denmark |
|
|
|
| | The Buck Institute – San Francisco, California, United States |
|
|
|
| | The University of Texas M. D. Anderson Cancer Center – Houston, Texas, United States |
|
|
|
| | University Hospital RWTH Aachen – Aachen, Germany |
|
|
|
| | King’s College London – London, England, United Kingdom |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
