 | | Vol. 18.28 – 19 July, 2023 |
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| Scientists compared in vitro signals from laminin (LN-511) and/or topographic cues to maintain stemness, using systematically-varied submicron pillar patterns or flat surfaces with or without preadsorbed LN-511.
[Biomaterials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that many DNA damage response and repair genes displayed differential alternative splicing in mouse ESCs compared to differentiated cells.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors reported controlled glial differentiation from hPSCs that bypassed neurogenesis, which otherwise preceded astrogliogenesis during brain development and in vitro differentiation.
[Stem Cell Reports] |
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| Scientists generated a systematic panel of transformed mouse embryonic fibroblasts using oncogenic transgenes and discovered transformed cell lines compatible with reprogramming when transfected with Oct4/Sox2/Klf4/Myc.
[Cell Death Discovery] |
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| Investigators derived skin fibroblasts from a patient with acute myelitis (P-HAF) and then reprogrammed P-HAF cells to iPSCs using eight exogenous factors.
[Frontiers in Cell and Developmental Biology] |
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| Discarded endometrial tissues were obtained from women receiving hysterectomy in their fourth and fifth decade due to benign uterine conditions. pCE-Sox2, Oct4, Klf4, L-Myc and Lin28 episomal vectors were used to electrotransfect the endometrial stromal cells.
[Tissue Engineering and Regenerative Medicine] |
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| Scientists found that core components of N6-methyl-adenosine (m6A) methyltransferase decreased during cardiomyocyte differentiation.
[Differentiation] |
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| As early embryogenesis depends on arachidonic acid (AA), researchers investigated the embryo protective effects of AA against the embryotoxic drug valproic acid. They studied the effects of AA on the proliferation and cell cycle parameters of PSCs.
[Reproductive Toxicology] |
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| Investigators generated hiPSCs using peripheral blood mononuclear cells derived from the patients and healthy siblings of familial nevoid basal cell carcinoma syndrome with the novel mutation in PTCH1_c.3298_3299insAAG in the feeder- and serum-free culture conditions.
[In Vitro Cellular & Developmental Biology – Animal] |
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| The authors summarize recent advances in the derivation of human trophoblast stem cells (hTSCs), with a focus on derivation from naive and primed hPSCs, as well as via reprogramming of somatic cells into induced hTSCs.
[Current Opinion in Genetics & Development] |
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| Hangzhou Qihan Biotech Co., Ltd. announced that the National Medical Products Administration (NMPA) approved its clinical trial application for the product QN-019a. It is the first IND approved in China for a gene-edited iPSC-derived cell therapy product.
[Qihan Biotech (Businesswire)] |
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| October 2 – 4, 2023
Boston, Massachusetts, United States |
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| | Yale School of Medicine – New Haven, Connecticut, United States |
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| | University of Galway – Galway, Ireland |
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| | University of Southern Denmark – Odense, Denmark |
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| | The Buck Institute – San Francisco, California, United States |
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| | University Hospital RWTH Aachen – Aachen, Germany |
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