 | | Vol. 18.29 – 26 July, 2023 |
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| Researchers developed a targeted proteomic proximity labeling approach to capture transposable element (TE)-associated proteins in hESCs. They found that the RNA N6-methyladenosine (m6A) reader, YTHDC2, occupied the genomic loci of the primate-specific TE, LTR7/HERV-H.
[Nature Genetics] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| By using Cas9 to edit the functional BRCA2 allele in the locally haploid hPSCs and in fibroblasts differentiated from them, scientists characterized essential regions in the gene to identify permissive and loss-of-function mutations.
[Nature Biomedical Engineering] |
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| To better understand totipotency, investigators carried out a genome-wide CRISPR knockout screen in mouse ESCs, searching for mutants that reactivate the expression of Dazl, a gene expressed in 2-cell-like cells.
[Nature Structural & Molecular Biology] |
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| Mouse ovarian granulosa cell derived-iPSCS were labelled with green fluorescent protein reporter and differentiated in vitro into oocytes.
[Ebiomedicine] |
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| On the basis of Yamanaka factors OSKM induction method, MEF cells were induced and reprogrammed into iPSCs under conditions of the oocyte-derived factor Wdr82 overexpression and/or knockdown, so as to assess the reprogramming efficiency.
[Cellular And Molecular Life Sciences] |
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| Using mouse chimeric embryos, constructed by injection of ESCs into the eight-cell embryo, as a tool, scientists aimed to explore the mechanisms underlying the regulatory nature of the preimplantation mouse embryo.
[Development] |
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| Transcriptome analysis revealed that Zfp296 deficiency in Zfp296-knockout ESCs up- and down-regulated a distinct group of genes, among which Dppa3, Otx2, and Pou3f1 were markedly downregulated.
[Communications Biology] |
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| Researchers demonstrated that a nuclear lncRNA linc1393 maintained mouse ESC pluripotency by recruiting SET1A near its binding sites, to establish H3K4me3 status and activate the expression of specific pluripotency-related genes.
[iScience] |
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| Given the importance of inositol 1,4,5-trisphosphate receptors (IP3Rs) in human diseases, the authors investigated their role in hiPSC by developing single IP3R and triple IP3R knockouts.
[Cell Calcium] |
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| Recent literature has uncovered important functions of the SIRT1-c-Myc axis in the regulation of maintenance and differentiation of stem cells, including PSCs and cancer stem cells. The authors highlight recent advances of the SIRT1-c-Myc axis in stem cells.
[Frontiers in Cell and Developmental Biology] |
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| Researchers from biotechnology startup Axonis will examine how microgravity affects the maturation of human brain cells that form three-dimensional spheroids that mimic certain aspects of the human brain.
[ISS National Laboratory] |
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| October 2 – 4, 2023
Boston, Massachusetts, United States |
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| | University of Cincinnati – Cincinnati, Ohio, United States |
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| | TU Dresden – Dresden, Germany |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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| | Yale School of Medicine – New Haven, Connecticut, United States |
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| | University of Galway – Galway, Ireland |
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