 | | Vol. 18.30 – 2 August, 2023 |
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| Investigators characterized the cell-cycle-associated transcriptome and proteome of mESCs in naive ground state.
[Molecular Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that disruptor of telomeric silencing 1-like (Dot1l) repressed endogenous retroviruses in ESCs. Specifically, the absence of Dot1l led to the activation of MERVL.
[Nucleic Acids Research] |
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| Scientists elucidated a previously unrecognized interconnectivity between the core pluripotent transcriptional network for the maintenance of human ESC self-renewal and NAT10-catalyzed N4-acetylcytidine RNA epigenetic modification.
[Nucleic Acids Research] |
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| The authors presented a spatial transcriptomic atlas of all major organs at embryonic day 13.5 in the mouse embryo, and provided a three-dimensional rendering of molecular regulation for embryonic patterning with stacked sections.
[Nature Communications] |
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| Researchers defined fatty acid metabolism as a key player in definitive endoderm differentiation from hESCs. Fatty acid β-oxidation was enhanced while lipogenesis was decreased, and this was due to the phosphorylation of lipogenic enzyme acetyl-CoA carboxylase by AMPK.
[Developmental Cell] |
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| Investigators developed optimal culture conditions to derive and propagate post-implantation epiblast-derived PSCs in rats, a valuable model for biomedical research.
[Cell Reports Methods] |
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| Researchers showed that POGZ played an important role in the maintenance of ESCs by silencing Dux and endogenous retroviruses.
[Cell Reports] |
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| Scientists combined optogenetic stimulation, imaging, and transcriptomic approaches to study self-organization of hESCs in 2D culture.
[Development] |
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| The expression of apurinic/apyrimidinic endonuclease 1 (APE1) was examined in mESCs by RT-qPCR and western blot. The role and mechanism of APE1 in the proliferation, pluripotency, and differentiation of E14 cells were determined by cell counting, flow cytometry, and western blot assays.
[Reproductive Biology] |
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| Rapidly evolving bioengineering approaches applied to hiPSC will undoubtedly become highly instrumental for investigating muscle pathophysiology and the development of therapeutic strategies.
[Journal of Neuromuscular Diseases] |
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| The authors highlight challenges with manipulating gene expression in hPSCs and their differentiated derivatives, and relevant solutions, transfection, transduction, transposition, and genomic safe harbor editing.
[FEBS Letters] |
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| The Kenya Medical Research Institute (KEMRI) commissioned the first- ever, state-of-the-art- Stem Cell and Regenerative Medicine Laboratory in Sub-Sahara African Region at its Central Laboratory Complex and Headquarters in Nairobi.
[Kenya Medical Research Institute] |
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| November 7 – 8, 2023
London, England, United Kingdom |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of Maryland – College Park, Maryland, United States |
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| | IRB Barcelona – Barcelona, Spain |
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| | Friedrich Miescher Institute for Biomedical Research – Basel, Switzerland |
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| | University of Cincinnati – Cincinnati, Ohio, United States |
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