 | | Vol. 18.31 – 9 August, 2023 |
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| Through screening of over 21,000 conditions, scientists developed a fast chemical reprogramming system, which significantly improved the kinetics of cell identity rewiring.
[Nature Cell Biology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors explored how the characteristics of the two types of alternative lengthening of telomere lines reflected their fates using multi-omics approaches.
[Nucleic Acids Research] |
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| Investigators performed genome-wide profiling of H3K9me3 in cumulus cell-derived somatic cell nuclear transfer (SCNT) embryos. They found redundant H3K9me3 marks were closely related to defective minor zygotic genome activation.
[Nature Communications] |
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| Using chromatin tracing, researchers analyzed X chromosome folding conformations in naïve and primed hPSCs with megabase genomic resolution.
[Science Advances] |
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| Scientists found that overexpression of Rhox6 favored the formation of primordial germ cell-like cells (PGCLCs), while depletion of Rhox6 inhibited the generation of PGCLCs.
[Cell & Bioscience] |
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| iPSCs were generated via a platelet lysate or fetal bovine serum-based culturing protocol from matched dermal, buccal, and gingival human fibroblasts, isolated from healthy donors after informed consent, via episomal plasmid transfection.
[Stem Cell Research & Therapy] |
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| To explore the mechanism for FAcilitates Chromatin Transactions (FACT) function, investigators generated auxin-inducible degron-tagged murine embryonic cell lines for FACT subunit suppressor of Ty 16 homolog and paired depletion with nascent transcription and chromatin accessibility analyses.
[BMC Biology] |
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| The high-efficiency human ESC-endothelial cell induction system was established in a previous study. Scientists applied single-cell RNA sequencing of the differentiated cells at different time points and investigated the gene expression profiles.
[Stem Cell Reviews and Reports] |
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| Using a low-input MNase-seq method, researchers showed that nucleosome positioning was globally obscured in zygotes but became well-defined during subsequent development.
[Europe Pmc] |
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| The authors outline the regulations related to PSC-derived cell-based therapeutic products in the founding regions of International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use.
[Stem Cell Reports] |
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| BlueRock Therapeutics LP and bit.bio announced a collaboration and option agreement for the discovery and manufacture of iPSC-derived Tregs for use in creating therapeutics. The collaboration leverages bit.bio’s machine learning-powered platform to identify transcription factor combinations for reprogramming iPSCs into Tregs.
[BlueRock Therapeutics] |
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| November 11 – 15, 2023
Nashville, Tennessee, United States |
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| | Center for Excellence in Molecular Cell Science – Shanghai, China |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of Maryland – College Park, Maryland, United States |
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| | IRB Barcelona – Barcelona, Spain |
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| | Friedrich Miescher Institute for Biomedical Research – Basel, Switzerland |
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