 | | Vol. 18.33 – 23 August, 2023 |
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| Investigators characterized the persistence and emergence of epigenetic memory and aberrations that emerge during reprogramming by performing genome-wide DNA methylation profiling throughout primed and naive reprogramming of human somatic cells to hiPSCs.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors reconstructed trajectories from the yolk sac hemogenic endothelium to early hematopoietic stem and progenitor cells.
[Science] |
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| Researchers showed that a subset of young LINE-1s, L1Md_Ts, were marked by the RNA polymerase II elongation factor ELL3, and functioned as enhancers in mouse ESCs.
[Nature Cell Biology] |
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| SOX2, SOX17, and SOX17FNV were all able to bind nucleosome core particles in vitro, which is a prerequisite for pioneer transcription factors.
[Nucleic Acids Research] |
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| Researchers reported that the overexpression of negative elongation factor A (Nelfa), a maternally provided factor, enhanced the conversion of ESCs into 2C-like cells in chemically defined conditions, while the deletion of endogenous Nelfa did not block this transition.
[Cell Proliferation] |
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| Scientists reported a rapid and simple protocol to differentiate motor neurons in monolayer culture using small molecules, which led to nearly pure neural stem cells in six days, robust OLIG2+ pMNs in 12 days, enriched CHAT+ cervical spinal MNs.
[Stem Cell Reports] |
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| Investigators used the in vitro differentiation of human pluripotent stem cells into cardiomyocytes to study the role of c-JUN. The knockout of c-JUN improved cardiomyocyte generation, as determined by the number of TNNT2+ cells.
[Life Science Alliance] |
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| The Arginine-Glycine-Aspartate motif was incorporated into a recombinant elastin-like peptide (REP). hESCs were treated with REP containing RGD motif during suspension and cryopreservation, and the survival rate was analyzed.
[Tissue Engineering And Regenerative Medicine] |
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| Researchers hypothesized that p66Shc could act as a negative regulator of ERK activity during embryonic development, antagonizing early lineage commitment. To explore the role of p66Shc in stem cell self-renewal and differentiation, they created a p66Shc knockout murine ESC line.
[Stem Cells And Development] |
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| Investigators describe the progress and challenges of corneal epithelial and endothelial regenerative medicine and the promising future of corneal regenerative medicine with iPS cells.
[Japanese Journal Of Ophthalmology] |
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| It is time for a redefinition of the human embryo, a team of researchers has proposed. Advances in recent years have shown that human stem cells can be used to make embryo-like structures, called embryo models, that can recreate some features of early embryo development.
[Nature News] |
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| Hongsik Jake Cho, PhD, associate professor at the University of Tennessee Health Science Center (UTHSC), recently received a $1.56 million Rehabilitation Research and Development Award from the US Department of Veterans Affairs to research next generation treatments for post-traumatic osteoarthritis.
[University of Tennessee Health Science Center] |
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| November 3 – 5, 2023
Huangshan, China |
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| | LifeArc – Stevenage, England, United Kingdom |
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| | RareCyte – Seattle, Washington, United States |
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| | Van Andel Institute – Grand Rapids, Michigan, United States |
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| | Creative Biolabs – New York, New York, United States |
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| | Technical University of Denmark – Kongens Lyngby, Denmark |
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