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Vol. 18.33 – 6 September, 2023
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Human fully integrated mouse Structured Stem cell-based Embryo Models with spatially organized morphogenesis recapitulated the organization of nearly all known lineages and compartments of post-implantation human embryos.
[Nature]
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PUBLICATIONSRanked by the impact factor of the journal
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The authors showed that Mcm2-mutated or Pole3-deleted mouse embryonic stem cells (ESCs) displayed aberrant histone landscapes and impaired neural differentiation.
[Nature Genetics]
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Researchers showed that Ascl1 and Ngn2 induced mutually exclusive side populations by binding and activating distinct lineage drivers.
[Nature Communications]
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Scientists generated a human astrocyte model carrying the APOE3 or APOE4 genotype using hiPSCs in which isogenic APOE4 iPSCs were genome edited from healthy control APOE3 iPSCs.
[Stem Cell Reports]
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Investigators described a method to improve iNeutrophil differentiations through the deletion of GATA1. GATA1 knockout iNeutrophils were nearly identical to primary neutrophils in form and function.
[iScience]
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The authors identified that DAXX, an H3.3 chaperone essential for the maintenance of ESCs in the ground state, accumulated in pericentromeric regions independently of DNA methylation.
[Journal Of Cell Science]
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Researchers generated an iPSC line from a patient with epileptic encephalopathy caused by the CYFIP2 R87C variant. They obtained iPSC clones by reprogramming urinary progenitor cells from a female patient.
[Human Cell]
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Using a deconvolution algorithm that employs pooled sequencing of single-nucleotide polymorphisms, scientists accurately estimated individual donor proportions of the pooled iPSCs.
[Stem Cell Reports Methods]
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The authors established a bleomycin (BLM)-induced pulmonary fibrosis mice model and administered human embryonic stem cell exosomes from the first day after BLM treatment.
[Current Stem Cell Research & Therapy]
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Recent technological advances have unveiled molecular features that characterize totipotent cells. Single-cell or low-input sequencing technologies allow the dissection of pre- and post-fertilization developmental processes at the molecular level with high resolution.
[Life Science Alliance]
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KAN Research Trust, promoted by Indian entrepreneur Ashok Soota and the UK-based Wellcome-MRC Cambridge Stem Cell Institute, is all set to bring to India cutting-edge expertise in stem cell research through a series of partnership agreements that were concluded today in Cambridge.
[SKAN Research Trust]
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September 22 – 24, 2023
Ribeirao Preto, Brazil
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Boehringer Ingelheim International – Biberach, Germany
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Royal Infirmary – Edinburgh, Scotland, United Kingdom
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Royal Infirmary – Edinburgh, Scotland, United Kingdom
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Amgen – Burnaby, British Columbia, Canada
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RareCyte – Seattle, Washington, United States
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