 | | Vol. 18.34 – 30 August, 2023 |
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| Researchers differentiated murine PSCs into self-renewing lung epithelial progenitors able to engraft into the injured distal lung epithelium of immunocompetent, syngeneic mouse recipients.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To advance our understanding of histone chaperone activity in vivo, scientists developed two Daxx mutant alleles in the mouse germline, which abolish the interactions between Daxx and Atrx, and Daxx and H3.3
[Cell Death & Disease] |
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| The authors reported that Haspin knockout mouse (m)ESCs had increased ratio of asymmetric cell division, which cumulatively regulated cell fate decisions. Furthermore, Wnt5a was significantly downregulated due to decreased Pax2 in Haspin-KO mESCs.
[Cell Death Discovery] |
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| Investigators determined the effects of low concentrations of MeHg exposure during the differentiation of definitive endoderm (DE) cells from human ESCs. hESCs were exposed to MeHg that covered the range of Hg concentrations typically found in human maternal blood during DE cell induction.
[Archives Of Toxicology] |
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| The authors produced hiPSC from three aniridia-associated keratopathy patients and examined whether PAX6 haploinsufficiency affected limbal stem cell lineage commitment.
[Stem Cells] |
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| Scientistss investigated the role of ice recrystallization inhibitors (IRIs) as novel cryoprotectants for iPSCs and terminally differentiated iPSC-Ns. They found that one class of IRIs, N-aryl-D-aldonamides, increased iPSC post-thaw viability and recovery with no adverse effect on iPSC pluripotency.
[Stem Cells] |
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| Data revealed that both ESCs and ESC-derived neurons did not show strong defects in the clearance of protein aggregates upon knockout of p62 or NBR1 and upon mutation of the p62 ubiquitin-associated domain and the LC3-interacting region motif.
[Life Science Alliance] |
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| Investigators developed a new method of parathyroid cell differentiation from hiPS cells. The parathyroid cell differentiation occurred in accordance with embryologic development.
[Stem Cells And Development] |
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| Researchers showed that Wnt signaling had a general posteriorising effect on stem cell aggregates and directed differentiation towards the mesoderm, as confirmed through the upregulation of posterior and mesodermal markers.
[Biology Open] |
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| YAP and TAZ translate complex biological cues acting on stem cells — from mechanical forces to cellular metabolism — into genome-wide effects to mediate stem cell functions.
[Nature Reviews Molecular Cell Biology] |
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| To understand their function in the pluripotency maintenance, researchers visualised and quantified the dynamics of single molecules of Nanog and Oct4 in a mouse ESCs during pluripotency loss.
[EMBO Journal] |
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| Bayer said an experimental stem cell therapy developed by its US subsidiary BlueRock had shown signs of easing Parkinson’s disease symptoms in an early 12-patient trial.
[Reuters] |
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| The Honourable Randy Boissonnault, Minister of Employment, Workforce Development & Official Languages and the Honourable Mark Holland, Minister of Health announced more than $96 million to support 329 research infrastructure projects at 54 universities across the country.
[nan] |
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| October 19 – 22, 2023
Minneapolis, Minnesota, United States |
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| | Royal Infirmary – Edinburgh, Scotland, United Kingdom |
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| | Duke University – Durham, North Carolina, United States |
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| | Amgen – Burnaby, British Columbia, Canada |
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| | RareCyte – Seattle, Washington, United States |
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| | Van Andel Institute – Grand Rapids, Michigan, United States |
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