 | | Vol. 18.34 – 13 September, 2023 |
| |
|
|
| Investigators showed that N6-methyladenosine (m6A) RNA methylation by Mettl3 was required for developmental pausing in mouse blastocysts and embryonic stem cells.
[Nature Cell Biology] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| To produce human cells with superior intra-niche competitiveness, the authors combined optimized pluripotent stem cell culture conditions with the inducible overexpression of two pro-survival genes.
[Cell Stem Cell] |
|
|
|
| DUX4 expression activated the DUX4-regulated ZGA transcriptional program, the subsequent 8C-like program, and markers of early embryonic lineages, while suppressing steady-state and interferon-induced MHC class I expression.
[Cell Reports] |
|
|
|
| The authors showed that checkpoint kinase 1 (CHK1) regulated cell cycle progression in early mouse embryos by restraining CDK1 kinase activity due to CDC25A phosphatase degradation.
[EMBO Reports] |
|
|
|
| Scientists comprehensively obtained the 17 sets of cellular mRNA transcriptomic data with 3.93 × 1010 bp raw reads and 18 sets of exosomal miRNA transcriptomic data with 2.83 × 107 bp raw reads from three categories of human somatic cells: peripheral blood mononuclear cells, skin fibroblasts and urine cells, along with their derived iPSCs.
[Scientific Data] |
|
|
|
| Researchers successfully differentiated and established a pure culture of melanocytes. The melanocytes maintained their growth rate for a long time, approximately 200 days, and were functional.
[Stem Cell Research & Therapy] |
|
|
|
| Investigators developed a plate with multiple dots containing a chemical substrate for the iPSC scaffold. iPSCs placed in the plate expanded only on the dots and created colonies of the same size. The cells were then differentiated into monocytes by adding cytokines to the colonies.
[Cytotherapy] |
|
|
|
| By employing low-input DNase-seq, researchers profiled the landscapes of chromatin accessibility in porcine early embryos and uncovered a unique chromatin accessibility reprogramming pattern during porcine preimplantation development.
[Science China Life Sciences] |
|
|
|
| Three hESC lines were successfully derived on the vitronectin with a truncated N-terminus in combination with E-cadherin in xeno-free conditions for the first time, and their undifferentiated state, hESC morphology, and standard karyotypes together with their potential to differentiate into three germ layers were confirmed.
[Scientific Reports] |
|
|
|
| The authors developed a strategy to improve the efficiency of the iPSC gene editing process via application of a small-molecule, trichostatin A, a Class I and II histone deacetylase inhibitor.
[CRISPR Journal] |
|  |
|
|
|
| Scientists summarize recent approaches used to promote hiPSC-cardiomyocyte (CM) proliferation, and thoroughly review recent advances in promoting hiPSC-CM maturation, which will serve as the foundation for large-scale production of mature hiPSC-CMs for future clinical applications.
[Stem Cell Research & Therapy] |
|
|
|
|
| The Stem Cell Network (SCN) announced $1 million in funding to support research trainees across Canada who are actively engaged in SCN’s 56 ongoing projects and clinical trials.
[Stem Cell Network] |
|
|
|
|
| October 22 – 25, 2023
Salt Lake City, Utah, United States |
|
|
|
|
|
| | University of Cambridge – Cambridge, England, United Kingdom |
|
|
|
| | Boehringer Ingelheim International – Biberach, Germany |
|
|
|
| | Royal Infirmary – Edinburgh, Scotland, United Kingdom |
|
|
|
| | Duke University – Durham, North Carolina, United States |
|
|
|
| | Amgen – Burnaby, British Columbia, Canada |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
