ESC & iPSC News Volume 18.35 | Sep 20 2023

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    2023-09-20 | ESC 18.35


    ESC & iPSC News by STEMCELL Technologies
    Vol. 18.35 – 20 September, 2023
    TOP STORY

    DMRT1 Regulates Human Germline Commitment

    Investigators followed the progression of nascent primordial germ cell (PGC)-like cells derived from human ESCs in vitro. They showed that switching from BMP signaling for PGC specification to Activin A and retinoic acid resulted in DMRT1 and CDH5 expression.
    [Nature Cell Biology]

    Full Article
    Learn how to avoid jargon and use blogs and social media channels to inform the public about your science
    PUBLICATIONSRanked by the impact factor of the journal

    Monolayer Platform to Generate and Purify Primordial Germ-Like Cells In Vitro Provides Insights into Human Germline Specification

    The authors developed a simplified, monolayer method to differentiate hPSCs into primordial germ cells within three and a half days.
    [Nature Communications]

    Full Article

    Metabolic Reprogramming via ACOD1 Depletion Enhances Function of Human Induced Pluripotent Stem Cell-Derived CAR-Macrophages in Solid Tumors

    Scientists found, via a pooled metabolic gene knockout CRISPR screen that KEAP1 and Aconitate decarboxylase 1 (ACOD1) were strong regulators of the pro-inflammatory state in macrophages.
    [Nature Communications]

    Full Article

    The COPD GWAS Gene ADGRG6 Instructs Function and Injury Response in Human iPSC-Derived Type II Alveolar Epithelial Cells

    Researchers applied an inducible CRISPR interference hiPSCs platform to explore ADGRG6 function in iPSC-derived human type 2 alveolar epithelial cells.
    [American Journal of Human Genetics]

    Full ArticleGraphical Abstract

    Derivation of Naïve Human Embryonic Stem Cells Using a CHK1 Inhibitor

    Investigators showed that exposure of frozen human blastocysts to an inhibitor of checkpoint kinase 1 (CHK1) upon thaw greatly enhanced establishment of karyotypically normal late naïve human ESC cultures.
    [Stem Cell Reviews and Reports]

    Full ArticleGraphical Abstract

    Mini-TCRs: Truncated T Cell Receptors to Generate T Cells from Induced Pluripotent Stem Cells

    Scientists presented the development of truncated T cell receptor (TCR) α and TCRβ chains, termed “Mini-TCRs”. They successfully induced cytotoxic T lymphocytes from iPSCs by employing Mini-TCRs.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractFull ArticleGraphical Abstract

    Accelerated Differentiation of Human Induced Pluripotent Stem Cells into Regionally Specific Dorsal and Ventral Spinal Neural Progenitor Cells for Application in Spinal Cord Therapeutics

    Building upon previous work that demonstrated the rapid establishment of a primitive ectoderm population from hiPSCs, researchers described the production of a diverse population of both ventral spinal and dorsal horn progenitor cells.
    [Frontiers in Neuroscience]

    Full Article

    Deepening the Role of Excitation/Inhibition Balance in Human iPSCs-Derived Neuronal Networks Coupled to MEAs during Long-Term Development

    The authors investigated whether and how the balance between excitation and inhibition influenced the spontaneous development of human-derived neuronal networks in vitro.
    [Journal of Neural Engineering]

    Full Article

    Cardiac Involvement in Patient-Specific Induced Pluripotent Stem Cells of Myotonic Dystrophy Type 1: Unveiling the Impact of Voltage-Gated Sodium Channels

    Scientists identified two myotonic dystrophy type 1 patients with heart conduction abnormalities and characterized their hiPSC lines.
    [Frontiers in Physiology]

    Full Article
    Facts Vs. claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.
    REVIEWS

    Induced Pluripotent Stem Cells in Disease Biology and the Evidence for Their In Vitro Utility

    Investigators summarize the particular challenges presented by each organ system and describe how iPSC models are being used to address them.
    [Annual Review of Genetics]

    Abstract
    INDUSTRY AND POLICY NEWS

    Human Trials of Artificial Wombs Could Start Soon. Here’s What You Need to Know

    Researchers at the Children’s Hospital of Philadelphia have begun seeking approval for the first human clinical trials of the device they’ve been testing, named the Extra-uterine Environment for Newborn Development, or EXTEND.
    [Nature News]

    Press Release
    FEATURED EVENT

    AACR-KCA Joint Conference on Precision Medicine in Cancer

    November 15 – 17, 2023
    Seoul, Korea

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    JOB OPPORTUNITIES

    Research Positions – Pluripotent Stem Cell, Lung Differentiation, and Genomics

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Position – Stem Cell Manufacturing

    Technical University of Denmark – Copenhagen, Denmark

    Postdoctoral Grant – Retinal Diseases

    Boehringer Ingelheim International – Biberach, Germany

    Postdoctoral Research Fellow – iPSC Models of Parkinson’s Disease

    Royal Infirmary – Edinburgh, Scotland, United Kingdom

    Assistant Professor – Neural Networks for Biology

    Duke University – Durham, North Carolina, United States

    > See All Jobs

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