 | | Vol. 18.36 – 27 September, 2023 |
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| Scientists studied the consequences of the hexanucleotide repeat expansion mutation in C9orf72 for microglial function using human iPSC-derived microglia.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators presented an efficient stepwise differentiation method to generate human pharyngeal foregut endoderm from PSCs.
[Developmental Cell] |
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| To dissect X-dosage effects on the signaling network in mESCs, the authors combined systematic perturbation experiments with mathematical modeling.
[Molecular Systems Biology] |
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| Scientists showed that the lncRNA-associated protein TOBF1 modulated the alternative splicing of transcripts necessary for maintaining stem cell identity in mouse ESCs.
[Cell Reports] |
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| The authors tested the hypothesis that the PPP2R2B antisense transcript containing a CUG repeat was expressed and contributes to spinocerebellar ataxia type 12 pathogenesis.
[Movement Disorders] |
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| Researchers aimed to determine the effects on energy metabolism and differentiation ability of mouse ESCs following deletion of the mitochondrial fission-related gene Dnml1.
[Cellular and Molecular Life Sciences] |
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| Investigators developed a method to generate three-dimensional myelin spheroids from hiPSCs in a robust and reproducible manner.
[iScience] |
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| Researchers evaluated the potential beneficial effects of iPSC-derived extracellular vesicles in an in vitro model of fibrosis using mouse mesangial cells stimulated with transforming growth factor beta.
[Scientific Reports] |
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| Scientists described scalable techniques for generating 10,000–100,000 organoids that further matured in four to five weeks into α- and β-like cells with glucose-responsive insulin and glucagon release.
[Star Protocols] |
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| The authors review the recent advances in patients-derived iPSCs as ex vivo models for mitochondrial diseases. Patients-derived iPSCs have been differentiated into specific targeting cells such as retinal ganglion cells and eventually organoid for the disease modeling.
[Journal of Biomedical Science] |
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| Despite negative feedback from the research community, the US National Institutes of Health (NIH) has decided to move forward with a policy requiring that foreign scientists receiving ‘subawards’ from the agency must share their laboratory notebooks and other raw data with their research partner in the US.
[Nature News] |
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| November 26 – 29, 2023
Buxted Park, England, United Kingdom |
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| | Helmholtz Association of German Research Centres – Berlin, Germany |
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| | Technical University of Denmark – Copenhagen, Denmark |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Boehringer Ingelheim International – Biberach, Germany |
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| | Duke University – Durham, North Carolina, United States |
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