 | | Vol. 18.37 – 4 October, 2023 |
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| Scientists described a protocol for improved specification of nephron progenitors from hPSCs that resulted in kidney organoids with elongated proximalized nephrons displaying improved proximal tubule maturity.
[Nature Protocols] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors found that capacitated hPSCs were transcriptionally closer to postimplantation epiblast than conventional hPSCs. They also found that capacitated hPSCs acquired an epigenetic state similar to conventional hPSCs.
[Science Advances] |
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| Scientists reported on DNA damage signaling, cell cycle, and transcriptome-level changes in hiPSCs in response to telomere-internal double-strand breaks.
[Journal of Molecular Cell Biology] |
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| Researchers investigated the role of YAP, Yorkie homolog, during the hematopoietic differentiation of hiPSCs to hematopoietic stem/progenitor cells and erythrocytes using the isogenic YAP-overexpressing and YAP-depleting hiPSCs.
[Stem Cell Research & Therapy] |
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| Investigators presented a transgene-free method for the generation of purified, expandable myogenic progenitors from hiPSCs grown under feeder-free conditions.
[Stem Cell Reports] |
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| Researchers used human in vitro PSCs and single-cell RNA sequencing to recapitulate the molecular events during sympathoadrenal development.
[iScience] |
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| Scientists described in detail the protocols to derive and maintain PSC-trophoblast stem cell, from both ESC and patient-derived iPSC, and their subsequent terminal differentiation to syncytiotrophoblasts and extravillous trophoblasts.
[Current Protocols] |
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| Researchers developed a highly sensitive assay to detect residual undifferentiated cells in islet cells derived from human chemically induced pluripotent stem cells, which were transgene-free and safer.
[Scientific Reports] |
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| Investigators reported a novel function of Zfp352, one of the 2-cell specific genes, in regulating the 2-cell-gene labeled cell sub-population. They suggested the dual roles of Zfp352 in regulating the transient activation of the 2-cell-specific genes.
[Genes to Cells] |
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| The authors summarize the evolution of iPSCs technology and its applications in malignant solid tumors. Additionally, they discuss potential obstacles to iPSC technology.
[Stem Cell Reviews and Reports] |
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| Associate Professor Mark Denham at the Danish Research Institute of Translational Neuroscience, also known as DANDRITE at Aarhus University, has recently obtained a patent for a research method that he has refined over the past decade.
[Aarhus University] |
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| October 23 – 25, 2023
Toronto, Ontario, Canada |
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| | St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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| | Medical University of South Carolina – Charleston, South Carolina, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Technical University of Denmark – Copenhagen, Denmark |
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| | Helmholtz Association of German Research Centres – Berlin, Germany |
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