ESC & iPSC News Volume 18.38 | Oct 11 2023

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    2023-10-11 | ESC 18.38


    ESC & iPSC News by STEMCELL Technologies
    Vol. 18.38 – 11 October, 2023
    TOP STORY

    Preclinical Quality, Safety, and Efficacy of a Human Embryonic Stem Cell-Derived Product for the Treatment of Parkinson’s Disease, STEM-PD

    Scientists presented quality, safety, and efficacy data supporting the first-in-human STEM-Parkinson’s disease (PD) phase I/IIa clinical trial along with the trial design.
    [Cell Stem Cell]

    Full ArticleGraphical Abstract
    Learn about Parkinson's Disease therapy with hESCs by watching Dr. Malin Parmar's webinar from the Nature Research Round Table on hPSC Quality
    PUBLICATIONSRanked by the impact factor of the journal

    Assembly of Complete Mouse Embryo Models from Embryonic and Induced Stem Cell Types In Vitro

    Investigators described a protocol to assemble a complete mouse embryo model using mESCs and induced ESCs to express Cdx2 and Gata4 to reconstitute the epiblast, extraembryonic ectoderm, and visceral endoderm lineages, respectively.
    [Nature Protocols]

    Abstract

    In Need of Age-Appropriate Cardiac Models: Impact of Cell Age on Extracellular Matrix Therapy Outcomes

    Using aged iPSC-derived cardiomyocytes, the authors studied the effect of cell age on the young extracellular matrix therapy, an emerging approach for myocardial infarction treatment and prevention.
    [Aging Cell]

    Full Article

    The Efficient Generation of Functional Human Hepatocytes from Chemically Induced Pluripotent Stem Cells

    Researchers developed a differentiation protocol by mimicking the two-stage development of hepatoblasts, which permited the efficient generation of hepatic progenitor cells from chemically induced iPSCs.
    [Cell Proliferation]

    Full Article

    Human Pluripotent Stem Cell-Derived Inner Ear Organoids Recapitulate Otic Development In Vitro

    Scientists provided the first direct comparisons of the early human embryonic otocyst and fetal sensory organs with human inner ear organoids.
    [Development]

    Abstract

    Transcriptomic Analysis of PADI4 Target Genes during Multi-Lineage Differentiation of Embryonic Stem Cells

    The authors examined the role of peptidylarginine deiminase IV (PADI4) in maintaining the multi-lineage differentiation potential of mouse ESCs.
    [Philosophical Transactions Of The Royal Society B-Biological Sciences]

    Full Article

    Blastomeres of 8-Cell Mouse Embryos Differ in Their Ability to Generate Embryonic Stem Cells and Produce Lines with Different Transcriptional Signatures

    Investigators assessed the ability of 8-cell blastomeres to produce epiblast cells and ESC lines after isolation, and the properties of the resulting lines.
    [Frontiers In Cell And Developmental Biology]

    Full Article

    Isogenic Pairs of Induced-Pluripotent Stem-Derived Endothelial Cells Identify DYRK1A/PPARG/EGR1 Pathway Is Responsible for Down Syndrome-Associated Pulmonary Hypertension

    Researchers analyzed the human vascular endothelial cells by utilizing the isogenic pairs of T21-iPSCs and corrected disomy 21-iPSCs.
    [Human Molecular Genetics]

    AbstractGraphical Abstract

    Modeling of Intramembranous Ossification Using Human Pluripotent Stem Cell-Derived Paraxial Mesoderm Derivatives

    Scientists developed a human PSC-based system that modeled the human intramembranous ossification process. They found that spheroid culture of the hPSC-derived paraxial mesoderm derivatives generated osteoprogenitors or osteo-chondroprogenitors depending on stimuli.
    [Regenerative Therapy]

    Full Article
    Dr. Kristina McBurney and Leanna Bedell discuss how you can use social media to advance your scientific career. Watch now.
    REVIEWS

    Preparation of Astrocytes by Directed Differentiation of Pluripotent Stem Cells and Somatic Cell Transdifferentiation

    The authors evaluate the preparation of primary astrocytes (ACs), its limitations, as well as the importance of obtaining high-quality ACs. Additionally, they provide an updated review of the research progress in this field.
    [Developmental Neurobiology]

    Abstract
    INDUSTRY AND POLICY NEWS

    BU Researcher Receives Funds for AATD Research

    Andrew A. Wilson, MD, of Boston University (BU) Chobanian & Avedisian School of Medicine, has recently received a gift of $100,000 to establish the Katharine Howe Lovett Fund for Alpha-1 antitrypsin deficiency (AATD) Research.
    [Boston University]

    Press Release
    FEATURED EVENT

    Donor Selection & Cell Source Summit

    November 28 – 30, 2023
    San Francisco, California, United States

    > See All Events

    JOB OPPORTUNITIES

    Technician – iPSC NIM

    Luxembourg Centre for Systems Biomedicine – Luxembourg, Luxembourg

    Faculty Positions – Primate Biomedical Research

    Kunming University of Science and Technology – Kunming, China

    PhD Position – Cell Fate Engineering & Disease Modeling

    St. Anna Children’s Cancer Research Institute – Vienna, Austria

    Faculty Position – Regenerative Medicine and Cell Biology

    Medical University of South Carolina – Charleston, South Carolina, United States

    Research Positions – Pluripotent Stem Cell, Lung Differentiation, and Genomics Project

    The University of British Columbia – Vancouver, British Columbia, Canada

    > See All Jobs

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