 | | Vol. 18.39 – 18 October, 2023 |
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| Investigators engineered isogenic knockout human ESC lines for 20 genes associated with type 2 diabetes risk. They examined the impacts of each knockout on β cell differentiation, functions, and survival.
[Cell Metabolism] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| A bioengineering strategy to create muscle connective tissue-layered myofibers through the development of stem cell fate-controlling biomaterials that achieved both myogenesis and fibroblast differentiation in a locally controlled manner at the single construct was introduced.
[Advanced Functional Materials] |
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| Scientists performed a comprehensive comparison of mouse germ cell development in vitro over all culture steps versus in vivo with the goal of understanding mechanisms underlying poor oocyte quality.
[EMBO Journal] |
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| To understand whether complex haploinsufficiency exists in pluripotent cells, researchers simultaneously eliminated a single allele in different combinations of two pluripotency genes.
[Stem Cell Reports] |
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| Investigators utilized a factorial experimental design coupled with statistical modeling to understand which signaling pathways were involved in the transition between ESCs and early primitive ectoderm-like cells.
[Development] |
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| Scientists employed single-cell RNA-sequencing with high temporal precision, alongside an optimized differentiation protocol, to elucidate the transcriptional hierarchy of lung specification to chart the associated single-cell trajectories.
[iScience] |
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| The authors showed that vitamin C increased the expression of several transposable element families, including evolutionarily young LINE-1 elements, in mouse ESCs.
[Epigenetics & Chromatin] |
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| Researchers described the production of shape-designable cartilage using a novel cell self-aggregation technique and chondroprogenitor cells derived from hiPSCs as the source.
[Biomedical Materials] |
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| Investigators used iPSCs derived from Takenouchi-Kosaki Syndrome (TKS) patients to model the disease and successfully recapitulated macrothrombocytopenia, a prominent TKS phenotype.
[Stem Cell Research] |
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| The authors provide a comprehensive scoping review of iPSC methods specifically applied to a broad range of addictive drugs/substances that lead to substance use disorders or misuse behavior.
[PLOS One] |
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| Scientists in Argentina are on edge as the country’s presidential election approaches. If elected president, economist Javier Milei has pledged to eliminate government spending on research and shut down the environment and health ministries.
[Nature] |
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| November 28 – 30, 2023
Philadelphia, Pennsylvania, United States |
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| | EPFL – Lausanne, Switzerland |
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| | Centre for Trophoblast Research – Cambridge, England, United Kingdom |
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| | Luxembourg Centre for Systems Biomedicine – Luxembourg, Luxembourg |
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| | Kunming University of Science and Technology – Kunming, China |
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| | St. Anna Children’s Cancer Research Institute – Vienna, Austria |
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