 | | Vol. 18.42 – 25 October, 2023 |
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| Investigators demonstrated that impaired bromodomain-containing protein 9 (BRD9) function reduced the self-renewal capacity of hESCs and altered their differentiation potential.
[Nucleic Acids Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors described a mESC and mouse line harboring a degron-tagged Eomes allele, which enabled rapid and reversible protein degradation upon administration of degradation fusion tag.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers reported that ZEB1 and ZEB2 promoted and inhibited mesodermal-to-myogenic specification of hESCs, respectively.
[Cell Reports] |
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| Scientists applied a combination of single-cell technology and genetic analysis to investigate the dynamic transcriptional changes associated with Drosophila embryo morphogenesis at gastrulation.
[Cell Reports] |
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| Investigators showed that zinc finger and SCAN domain containing 4 (ZSCAN4) promoted DNA repair by acting with poly (ADP-ribose) polymerase 1 (PARP1), which is a key member of the alt-NHEJ pathway.
[Cell & Bioscience] |
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| Researchers showed that the thyroid hormone triiodothyronine enhanced reprogramming of mouse embryonic fibroblasts into iPSCs by the Yamanaka factors.
[Frontiers in Endocrinology] |
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| Scientists utilized ESCs to explore the impact of exposure to zearalenone. A mitochondrial division inhibitor was also included as a reference.
[Food and Chemical Toxicology] |
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| Patient‑derived iPSCs were generated by reprogramming peripheral blood mononuclear cells obtained from two groups of gefitinib‑treated patients with severe hepatotoxicity or mild hepatotoxicity.
[Oncology Letters] |
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| The authors examine ESC & iPSC cell lines originating from marmoset, cynomolgus macaque, rhesus macaque, pig-tailed macaque, Japanese macaque, African green monkey, baboon, chimpanzee, bonobo, gorilla, and orangutan.
[Stem Cell Reports] |
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| Scientists summarize the current understanding of mitochondrial metabolism during somatic cell reprogramming to iPSCs and the metabolic shift that occurs during directed differentiation into pancreatic β-like cells.
[Frontiers in Endocrinology] |
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| Japan’s contribution to world-class research continues to decline, despite having one of the world’s largest research communities, according to a report by the Japanese Ministry of Education, Culture, Sports, Science and Technology.
[Nature] |
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| December 2 – 6, 2023
Boston, Massachusetts, United States |
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| | University of East Anglia – Norwich, England, United Kingdom |
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| | Indiana University School of Medicine- Indianapolis, Indiana, United States |
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| | EPFL – Lausanne, Switzerland |
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| | Luxembourg Centre for Systems Biomedicine – Luxembourg, Luxembourg |
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| | Kunming University of Science and Technology – Kunming, China |
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