 | | Vol. 18.43 – 1 November, 2023 |
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| Investigators identified specific transcriptional patterns that could serve as a biomarker for the selection of suitable iPSC clones for the successful development of antigen-specific CD8αβ+ memory T cells to improve multiple myeloma patient outcomes.
[Blood] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors revealed that cells decode the steady-state concentrations and timing of YAP activation to control proliferation, cell fate, and expression of the pluripotency regulators Oct4 and Nanog.
[Nature Communications] |
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| Scientists showed that proteotoxic stress visualized by the misfolded and/or aggregated proteins appeared during early cardiac differentiation of hPSCs and was resolved by activation of the protein kinase RNA-like ER kinase (PERK) branch of unfolded protein response.
[Advanced Science] |
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| The authors fabricated oxygen release biomaterials and developed an oxygenated scaffold culture platform to offer a better oxygen supply during 3D iPSC pancreatic differentiation.
[Advanced Healthcare Materials] |
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| Researchers designed a perfusion bioreactor for an hiPSC-laden, 3D-bioprinted chamber with the goal of proliferating the hiPSCs throughout the structure prior to differentiation to generate a thick tissue model.
[Biofabrication] |
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| Scientists reported the presence of short C-terminal Musashi-1 proteins in early mouse embryos and mouse ESCs, but not in human ESCs, under conventional culture conditions.
[Cell Reports] |
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| By analyzing the levels of two major nutrients, glycogen and neutral lipids, researchers discovered stage-dependent usage of these two nutrients along with mitochondrial morphology changes during Caenorhabditis elegans embryogenesis.
[EMBO Reports] |
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| Scientists developed a step-wise protocol that differentiated iPSCs from individuals homozygous for the C-C chemokine receptor type 5 (CCR5)Δ32 variant and healthy volunteers into myeloid lineage induced monocytes and macrophages.
[iScience] |
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| Researchers induced human primordial germ cell (PGC)-like cells (hPGCLCs) from hESCs and the derived hPGCLCs upregulated PGC-related genes, like SOX17, BLIMP1, TFAP2C, NANOS3, and the naïve pluripotency gene KLF4.
[Reproductive Sciences] |
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| Patient-derived iPSCs can provide a promising platform for pathological research and new drug discovery in the field of immune-related diseases.
[Inflammation and Regeneration] |
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| The group behind the radical open-access initiative Plan S has announced its next big plan to shake up research publishing — and this one could be bolder than the first. It wants all versions of an article and its associated peer-review reports to be published openly from the outset, without authors paying any fees.
[Nature News] |
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| December 4 – 6, 2023
Vienna, Austria |
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| | Case Western Reserve University – Cleveland, Ohio, United States |
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| | University of East Anglia – Norwich, England, United Kingdom |
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| | Indiana University School of Medicine- Indianapolis, Indiana, United States |
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| | EPFL – Lausanne, Switzerland |
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| | Luxembourg Centre for Systems Biomedicine – Luxembourg, Luxembourg |
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