 | | Vol. 18.44 – 8 November, 2023 |
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| Scientists generated microglia-sufficient brain organoids by coculturing brain organoids with primitive-like macrophages generated from the same human iPSCs.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators suggested that cytoplasmic lattices enrich maternally provided proteins to prevent their premature degradation and cellular activity, thereby enabling early mammalian development.
[Cell] |
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| Researchers investigated the role of nuclear receptor transcription factors, whose motifs were highly enriched and accessible from the 2-cell to 8-cell stages in mouse embryos.
[Cell Research] |
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| The authors reported the generation of large numbers of human-induced steroidogenic cells (hiSCs) from hPSCs. Directed differentiation of hPSCs into hiSCs recapitulates the initial stages of human adrenal development.
[Cell Reports Methods] |
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| Scientists utilized a factorial experimental design coupled with statistical modelling to understand which signaling pathways are involved in the transition between ESCs and early primitive ectoderm-like cells.
[Development] |
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| To test the implication of RET on the hematopoietic potential of iPSCs, researchers activated its pathway with the lentiviral overexpression of RETWT or RETC634Y mutation in normal iPSCs.
[Cytotherapy] |
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| Scientists performed biological analyses to identify the key components involved in glutamate biosynthesis, packaging for secretion, reaction, and reuptake in ESCs, including glutaminase, vesicular glutamate transporter, glutamate N-methyl-D-aspartate receptor, and cell membrane excitatory amino-acid transporter.
[Scientific Reports] |
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| Researchers reported a protocol for small molecule-mediated induction of the neural crest state from blastula stem cells and validated it using transcriptome analysis and grafting experiments.
[Developmental Biology] |
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| Investigators derived iPS cells from cat embryonic fibroblasts retrovirally transfected with mouse Oct3/4, Klf4, Sox2, and c-Myc. After transfection, embryonic fibroblasts were reseeded onto inactivated SNL 76/7 and cultured in a medium supplemented with basic fibroblast growth factor.
[Journal Of Reproduction And Development] |
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| The authors focus on the mechanism of the angiogenic effect of iPSCs-derived exosomes on wound repair in tissue injury and their potential therapeutic targets, with a view to providing a theoretical basis for the use of iPSCs-derived exosomes in clinical therapy.
[Angiology] |
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| The International Society for Stem Cell Research (ISSCR) and publisher Cell Press are extending their partnership to publish the ISSCR’s open access, peer-reviewed journal, Stem Cell Reports.
[The International Society for Stem Cell Research] |
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| As a Nobel laureate, Prof Frances Arnold is not short of accolades. Yet being the only woman to so far win the Millennium Technology Prize – the Nobel equivalent for engineers – is one of the least appealing.
[The Guardian] |
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| December 16 – 20, 2023
Waikoloa Beach, Hawaii, United States |
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| | Stony Brook University – Stony Brook, New York, United States |
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| | Case Western Reserve University – Cleveland, Ohio, United States |
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| | University of East Anglia – Norwich, England, United Kingdom |
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| | Indiana University School of Medicine- Indianapolis, Indiana, United States |
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| | EPFL – Lausanne, Switzerland |
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