 | | Vol. 18.45 – 15 November, 2023 |
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| The authors established single-cell RNA sequencing of the whole embryo as a scalable platform for the systematic phenotyping of mouse genetic models.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators systematically tested various culture conditions for establishing monkey naive ESCs and optimized the procedures for chimeric embryo culture.
[Cell] |
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| The authors showed that the expression of RYBP and YAF2 decreased and increased, respectively, during neural differentiation of ESCs. Rybp knockout impaired neural differentiation by activating Wnt signaling and derepressing nonneuroectoderm-associated genes.
[Nature Communications] |
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| Researchers designed a perfusion bioreactor for an hiPSC-laden, 3D-bioprinted chamber with the goal of proliferating the hiPSCs throughout the structure prior to differentiation to generate a thick tissue model.
[Biofabrication] |
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| Scientists performed pancreatic progenitor differentiation with and without AKT/P70 inhibitor AT7867 and characterized the resulting cells at protein and transcript level in vitro and in vivo upon transplantation into diabetic mice.
[Stem Cell Reports] |
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| hiPSCs were generated from control BJ and four disease fibroblast lines using a cocktail of non-modified reprogramming and immune evasion mRNAs and microRNAs.
[Current Stem Cell Research & Therapy] |
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| Researchers compared the osteoclastogenesis capacity of a peripheral blood mononuclear cell-derived iPSC line to a fibroblast-derived iPSC line in conjunction with either embryoid body-based or monolayer-based differentiation strategies.
[Current Stem Cell Research & Therapy] |
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| Researchers used a quantitative method of cellular telomerase activity based on a quartz crystal microbalance device to monitor the dynamic changes in cellular telomerase activity in hiPSCs during myocardial differentiation under chemically defined conditions.
[Biochemical And Biophysical Research Communications] |
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| The authors established two strains of iPSCs from skin fibroblasts of patients with childhood cerebral adrenoleukodystrophy and Addison’s disease, respectively. CytoTune™2.0 Sendai reprogramming kit was used.
[Stem Cell Research] |
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| For amyotrophic lateral sclerosis, a devastating neurodegenerative disease, several groups have identified candidate drugs, ezogabine, bosutinib, and ropinirole, using iPSCs-based drug discovery, and clinical trials using these drugs have been conducted, yielding interesting results.
[Journal Of Neurochemistry] |
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| Scientists have created an infant ‘chimeric’ monkey by injecting a monkey embryo with stem cells from a genetically distinct donor embryo1. The resulting animal is the first live-born chimaeric primate to have a high proportion of cells originating from donor stem cells.
[Nature] |
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| January 22 – 25, 2024
Santa Fe, New Mexico, United States |
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| | China Pharmaceutical University – Nanjing, Jiangsu, China |
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| | Stony Brook University – Stony Brook, New York, United States |
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| | Case Western Reserve University – Cleveland, Ohio, United States |
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| | University of East Anglia – Norwich, England, United Kingdom |
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| | Indiana University School of Medicine- Indianapolis, Indiana, United States |
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