 | | Vol. 18.46 – 22 November, 2023 |
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| Researchers uncovered a highly dynamic and oscillatory pattern of translational reprogramming that contributed to the translational regulation of specific mRNAs with different modes of polysomal occupancy/translation that were important for oocyte and embryo developmental competence.
[Nucleic Acids Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors found that ESCs were depleted for H3K79me2 at shared locations of enrichment with somatic cells, which were highly and ubiquitously expressed housekeeping genes, and had lower RNA polymerase II at the transcription start site despite greater nascent transcription.
[Science Advances] |
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| Investigators examined the glycosphingolipids profiles of extracellular vesicles secreted from human ESCs and investigated their functions in priming macrophages to enhance immune tolerance of embryo implantation.
[Developmental Cell] |
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| Scientists reported that human skeletal muscle organoids could be differentiated from iPSC lines to contain paraxial mesoderm and neuromesodermal progenitors and develop into organized structures reassembling neural plate border and dermomyotome.
[eLife] |
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| The authors established a model of mouse ESC differentiation and examined the dynamics of γH2AX foci during the process.
[Cells & Development] |
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| Human ESCcs were genetically modified to stably overexpress ferritin using the CRISPR-Cas9 system. Cellular toxicity associated with ferritin overexpression and manganese supplementation were assessed based on cell viability, proliferation, and metabolic activity.
[Current Stem Cell Research & Therapy] |
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| Investigators described the reprogramming of skin fibroblasts obtained from a healthy 59-year-old individual without Alzheimer’s disease.
[Stem Cell Research] |
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| Researchers generated a NCS1 knockout human hiPSC line using CRISPR-Cas9 genome editing. It showed regular expression of pluripotent markers, normal iPSC morphology and karyotype as well as no detectable off-target effects on top 6 potentially affected genes.
[Stem Cell Research] |
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| The authors increased functionality of cells derived from fetal tissues arises from increased proliferative capacity, ability to survive in culture, and developmental potential that is attenuated in adult tissues.
[Stem Cell Reports] |
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| Two researchers at the University of California San Diego received close to $10 million in grants from the California Institute of Regenerative Medicine, the agency announced.
[UC San Diego] |
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| February 14 – 18, 2024
Cancun, Mexico |
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| | Royal College of Surgeons in Ireland – Dulin, Ireland |
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| | Stonybrook University – York, England, United Kingdom |
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| | University of York – York, England, United Kingdom |
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| | Applied Stem Cell – Milpitas, California, United States |
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| | China Pharmaceutical University – Nanjing, Jiangsu, China |
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