 | | Vol. 18.47 – 29 November, 2023 |
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| Investigators showed that the overexpression of eight immunomodulatory transgenes in mouse ESCs was sufficient to immunologically ‘cloak’ the cells as well as tissues derived from them, allowing their survival for months in outbred and allogeneic inbred recipients.
[Nature Biomedical Engineering] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists injected GFP-tagged human ESC-derived MSCs (EMSCs) into mouse blastocysts. EMSCs survived well and penetrated both the inner cell mass and trophectoderm, correlating to the higher anti-apoptotic capability of EMSCs than hESCs.
[Cell Reports] |
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| The authors used 2D human lung organoid derived from hESCs, to investigate Cryptococcus neoformans-host interactions. C. neoformans is an opportunistic fungus acquired by inhalation that causes systemic mycosis mainly in immunocompromised individuals.
[Microbes And Infection] |
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| The authors provided a xeno-free method for single-cell cloning of CRISPRed iPSCs achieving a clonal survival of up to 70% within seven–ten days.
[Stem Cell Reports] |
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| Investigators developed a human brain organoid technique that generated self-organizing, single-rosette cortical organoids with reproducible size and structure at early timepoints.
[Stem Cell Reports] |
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| Researchers used weighted gene co-expression network analysis on transcriptomic data retrieved from RNA-seq and small RNA-seq experiments and reconstructed the core human pluripotency network consisting of 375 mRNA, 57 lncRNA and 207 miRNAs.
[Differentiation] |
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| The mechanism was investigated by regulating the WNT/β-catenin signaling pathway and autophagy flux. The results showed that inhibition of BRG1 decreased pluripotency-related gene expression in porcine iPSCs.
[Theriogenology] |
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| Researchers focused on the receptors of five gastrointestinal hormones, and established human iPSC lines that functionally expressed each receptor.
[FEBS Open Bio] |
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| Skin fibroblasts obtained from a five-year-old girl with genetically proven and clinically manifested mucopolysaccharidosis type VI were successfully transformed into iPSCs by using Sendai virus-based reprogramming vectors including the four Yamanaka factors.
[Stem Cell Research] |
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| Investigators focus on the status of patient-derived iPSCs and organoids in inherited retinal diseases in recent years concerning disease modeling and therapeutic exploration, along with potential challenges for translating laboratory research to clinical application.
[Current Stem Cell Research & Therapy] |
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| Two IICD faculty members, Elham Azizi – Herbert and Florence Irving Assistant Professor of Cancer Data Research and Assistant Professor of Biomedical Engineering – and José McFaline-Figueroa – Assistant Professor of Biomedical Engineering -, were among the 18 new Allen Distinguished Investigators.
[Columbia University] |
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| January 16 – 19, 2024
San Diego, California, United States & Virtual |
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| | University of California San Francisco – San Francisco, California, United States |
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| | China Pharmaceutical University – Nanjing, Jiangsu, China |
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| | Stony Brook University – Stony Brook, New York, United States |
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| | University of York – York, England, United Kingdom |
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| | Applied Stem Cell – Milpitas, California, United States |
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