 | | Vol. 18.48 – 6 December, 2023 |
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| The authors reported genetic and non-genetic approaches to generate authentic hypoblast cellsfrom naïve human PSCs.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers detail human embryonic limb development across space and time using single-cell and spatial transcriptomics. They demonstrated extensive diversification of cells from a few multipotent progenitors to myriad differentiated cell states, including several novel cell populations.
[Nature] |
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| Utilizing a unified culture condition that activates the FGF, TGF-β, and WNT pathways, investigators successfully derived ESCs, extrembryonic endoderm stem cells, and trophoblast stem cells from the three foundational tissues of mouse and cynomolgus monkey blastocysts.
[Cell] |
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| Scientists developed a system that accurately reported OCT4 protein levels in live cells and used it to reveal the trajectories of OCT4 in successful reprogramming.
[Science Advances] |
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| Investigators found that one of the master circadian regulators PER1 promoted virus-mediated reprogramming of mouse embryonic fibroblasts to induced neurons and iPSCs.
[PLOS Biology] |
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| The authors reported a transformation system that efficiently and stably convert spermatogonial stem cells into PSCs around 10 passages with the morphology similar to that of epiblast stem cells, which converted to ESC-like colonies after change with embryonic stem medium.
[Cell & Bioscience] |
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| Researchers showed that N-acetyltransferase 10 (NAT10)-mediated ac4C modification promoted ectoderm differentiation of hESCs by acetylating nuclear receptor subfamily 2 group F member 1 (NR2F1) mRNA to enhance translation efficiency
[Cell Proliferation] |
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| Scientists assessed the potential of the iPSC in modulating the expression of the cardinal genes of the Wnt pathway in a mouse model of idiopathic pulmonary fibrosis.
[Stem Cell Research & Therapy] |
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| The authors utilized a customized microfluidic platform to generate hiPSC-derived 3D otic sensory neurons. hiPSC-derived otic neuronal progenitors were cultured in hydrogel-embedded microfluidic channels over a 40-day period.
[Tissue Engineering Part A] |
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| Scientists discuss the limbal stem cell model and its broader relevance to other tissues, disease, and therapy.
[Stem Cell Reports] |
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| Investigators focuse on the status of patient-derived iPSCs and organoids in inherited retinal diseases in recent years concerning disease modeling and therapeutic exploration, along with potential challenges for translating laboratory research to clinical application.
[Current Stem Cell Research & Therapy] |
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| The whole genomes of 500,000 people in the UK Biobank will help researchers to probe our genetic code for links to disease.
[Nature News] |
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| February 21 – 24, 2024
San Antonio, Texas, United States |
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| | Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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| | University of California San Francisco – San Francisco, California, United States |
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| | University of Exeter – Exeter, England, United Kingdom |
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| | China Pharmaceutical University – Nanjing, Jiangsu, China |
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| | Applied Stem Cell – Milpitas, California, United States |
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