 | | Vol. 18.49 – 13 December, 2023 |
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| The authors showed that antigen-restricted mature T cells could be generated in vitro from PSCs edited via CRISPR to lack endogenous T cell receptors and class I major histocompatibility complexes.
[Nature Biomedical Engineering] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers found that heart organoids produced using a self-organization-driven developmental induction strategy were remarkably similar transcriptionally and morphologically to age-matched human embryonic hearts.
[Nature Communications] |
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| Using a CRISPR screen in mouse embryonic stem cells, investigators found that the cohesin regulator PDS5A links transcriptional silencing by Polycomb and 3D genome organization.
[Nature Communications] |
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| The authors evaluated the in vitro developmental toxicity and the possible underlying mode of action of DMSO extracts of a series of highly complex petroleum substances in the mouse ESC test, the zebrafish embryotoxicity test and the aryl hydrocarbon receptor reporter gene assay.
[Archives Of Toxicology] |
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| A metabolic kinetic model was developed to characterize the underlying mechanisms of iPSC culture process, which could predict cell response to environmental perturbation and support process control.
[Biotechnology And Bioengineering] |
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| Scientists used rice cell-made basic fibroblast growth factor (RbFGF) to propagate hESCs and hiPSCs for at least 8 passages. Both hESCs and hiPSCs cultured with RbFGF not only maintained the morphology but also the specific expression of PSCs.
[Stem Cells And Development] |
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| Researchers identified Ahcy as a direct target of OCT4 and unveiled that AHCY regulated the self-renewal and differentiation potency of mESCs through multiple mechanisms.
[Biology Of Reproduction] |
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| Pancreatic specification is essential for stem cell-derived β cells cell induction in vitro and low-quality pancreatic progenitor (PP) cells may convert into derivatives of non-pancreatic lineages both in vivo and in vitro, impeding PP-derived β cell safety and differentiation efficiency.
[Experimental Cell Research] |
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| Scientists presented investigations into the utility of hiPSC-derived small intestinal epithelial cells for pharmacokinetic, toxicological, and immunological studies, respectively.
[Biochemical And Biophysical Research Communications] |
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| Investigators describe a detailed account of the potential properties of different types of stem cells and provides a comprehensive review of their protective mechanisms, particularly mesenchymal stem cells, in premature ovarian insufficiency disorder.
[Heliyon] |
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| Leading scientists are calling for a change in the law to help IVF patients donate unused embryos to biomedical research after a collapse in donations over the past 15 years.
[The Guardian] |
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| The University of Toronto’s Medicine by Design initiative and CCRM, a non-profit that supports the development and commercialization of regenerative medicines, are launching a new strategic alliance that aims to unlock Toronto’s potential as a world-leading ecosystem for regenerative medicine.
[The University of Toronto] |
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| February 27 – 28, 2024
London, England, United Kingdom |
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| | Cedars-Sinai Board – Anaheim, California, United States |
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| | UCLA Blood Stem Cell Research Center – Los Angeles, California, United States |
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| | Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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| | University of California San Francisco – San Francisco, California, United States |
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| | University of Exeter – Exeter, England, United Kingdom |
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