 | | Vol. 19.00 – 10 January, 2024 |
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| Investigators presented a genetically inducible stem cell-derived embryoid model of early post-implantation human embryogenesis that captured the reciprocal co-development of embryonic tissue and extra-embryonic endoderm and mesoderm niche with early hematopoiesis.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors found that XIST spread across the X chromosome and induced dampening of X-linked gene expression in naive hPSCs. Surprisingly, XIST also targets specific autosomal regions, where it induces repressive chromatin changes and gene expression dampening.
[Cell] |
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| Scientists showed that mouse embryos in diapause were sustained by using lipids as primary energy source. In vitro, supplementation of embryos with the metabolite L-carnitine balances lipid consumption, put the embryos in deeper dormancy and boosted embryo longevity.
[Nature Cell Biology] |
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| Researchers showed that mouse ESCs captured the unique metabolic state of preimplantation embryos and proliferated in the absence of several essential amino acids.
[Nature Metabolism] |
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| Scientists achieved a direct transfer of human chromosome 6 or 21 as a model from hiPSCs as alternative human chromosome donors into CHO cells containing mouse artificial chromosome.
[Nucleic Acids Research] |
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| Using culture modeling of cellular transitions, researchers found that DNA methylation-free mouse ESCs with triple DNA methyltransferase knockout progressed through the continuum of pluripotency states but demonstrated skewed differentiation abilities toward neural versus other somatic lineages.
[Nature Structural & Molecular Biology] |
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| The authors used targeted proteomics of the mitotic bookmarking transcription factor ESRRB, an orphan nuclear receptor, to discover a large redundancy in mitotic binding among members of the protein super-family of nuclear receptors.
[Nature Structural & Molecular Biology] |
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| Investigators described a large-scale method for producing homogeneous hiPSC-derived cardiac spheroids and cardiac organoids without scaffolds using a porous 3D microwell substratum with a suction system.
[Cell Reports Methods] |
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| Researchers leveraged a stepwise in vitro differentiation system that captured the early embryonic developmental cascade to investigate the impact of exposure to the most abundant phytocannabinoid, Δ9-tetrahydrocannabinol.
[eLife] |
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| Immature oocytes, opportunistically retrieved from sexually inactive females, underwent first in vitro maturation and then in vitro fertilization via piezo-intracytoplasmic sperm injection.
[Scientific Reports] |
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| Investigators discuss how PSC-based models of development can be used to investigate cell- and tissue-autonomous temporal processes.
[Current Opinion In Genetics & Development] |
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| The authors discuss a set of six complementary hallmarks in the context of some of the best-understood adult stem cell niches.
[Cell Stem Cell] |
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| Deepcell has entered into a research collaboration with NVIDIA to accelerate the use of generative artificial intelligence (AI) in single cell research for cancer, stem cells and cell therapies.
[PharmaTimes] |
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| February 27 – 28, 2024
London, England, United Kingdom |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | Human Technopole – Milan, Italy |
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| | Guangzhou Institutes of Biomedicine and Health – Guangzhou, China |
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| | Cedars-Sinai Board – Anaheim, California, United States |
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| | Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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